We analyze seismograms recorded by four arrays (B1–B4) with 100 m station spacing and apertures of 4–8 km that cross the surface rupture 2019 Mw 7.1 Ridgecrest earthquake. The extend from B1 in northwest to B4 southeast rupture. Delay times between P wave arrivals associated ∼1,200 local earthquakes teleseismic events are used estimate velocity variations beneath arrays. Both waves travel faste...

Expression of G protein-regulated phospholipase C (PLC)b4 in the retina, lateral geniculate nucleus, and superior colliculus implies that PLC b4 may play a role in the mammalian visual process. A mouse line that lacks PLC b4 was generated and the physiological significance of PLC b4 in murine visual function was investigated. Behavioral tests using a shuttle box demonstrated that the mice lacki...

In our previous reports1) on an experiment in feeding adult volunteers with Escherichia coli O-111 B4 by means of the Miller Abbott double lumen tube, it was indicated that whether or not Escherichia coli O-111 B4 produces similar illness to acute bacterial food poisoning may depend upon the multiplication of these organisms in the small intestine of volunteers who have ingested certain amounts...

Alkaline phosphatase has been coupled to Griffonia simplicifolia I B4 isolectin using a one-step glutaraldehyde conjugation procedure. This enzyme-lectin conjugate (AP-GS I-B4) has been used to specifically detect plastic-bound natural and synthetic glycoproteins bearing alpha-D-galactopyranosyl end groups. The extent of reactivity of the AP-GS I-B4 with the glycoproteins appears to be proporti...

Although the cellular origin of Reed-Sternberg (RS) cells of classical Hodgkin's disease (HD) has been a controversial issue for many years, recent immunophenotypic and molecular studies have suggested that RS cells of a subset of classical HD cases may be related to B cells. To further define the immunophenotypic features and the differentiation stage of RS cells, a series of 56 HD samples, in...

Immunotoxins, composed of a monoclonal antibody conjugated to a protein toxin, mediate cell death through novel cytotoxic mechanisms. Anti-B4-blocked ricin (anti-B4-bR) recognizes CD19-positive cells, which includes most B-cell non-Hodgkin's lymphomas (NHLs). Previous Phase I clinical studies of anti-B4-bR, using both bolus and continuous dosing regimens, demonstrated no safety or efficacy adva...

Two 70-kD polypeptides, B3 and B4, are present in equivalent concentrations in the nucleus and cytoplasm of Xenopus oocytes. The objectives of this study were to determine if they (a) are members of the 70-kD family of heat shock proteins, and (b) recycle between the nuclear and cytoplasmic compartments. Evidence based on high-affinity binding to ATP, cross-reactivity of B3/B4-specific antibodi...

Lectins such as VVA-B4, which bind N-acetylgalactosaminyl (GalNAc)-terminated saccharides, selectively stain the neuromuscular junction, thus defining a synapse-specific carbohydrate. In seeking roles for this carbohydrate, we asked whether VVA-B4 affected the distribution of acetylcholine receptors (AChRs) on cultured muscle cells. We found that incubation of myotubes with VVA-B4 induced forma...

When cutaneous sections from the newborn rat were treated with alpha-fucosidase, Ulex europeus agglutinin I (UEA) binding to the cell surface of the differentiated cells in the epidermis was diminished and there was an appearance in these cell layers of binding by Bandeiraea simplicifolia I-B4 lectin (BS I-B4), which normally is specific for the basal cells. A similar treatment with alpha-galac...