Modulator compounds intended to overcome disease-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) show significant promise in clinical testing for cystic fibrosis. However, the mechanism(s) of action underlying these compounds are not fully understood. Activation of CFTR ion transport requires PKA-regulated phosphorylation of the regulatory domain (R-D) and di...

CF (cystic fibrosis) is caused by mutations in CFTR (CF transmembrane conductance regulator), which cause its mistrafficking and/or dysfunction as a regulated chloride channel on the apical surface of epithelia. CFTR is a member of the ABC (ATP-binding-cassette) superfamily of membrane proteins and a disease-causing missense mutation within the ABC signature sequence; G551D-CFTR exhibits defect...

The vestibular system is important for the development of normal movement reactions, motion tolerance, and motor control for postural alignment, balance, and vision. A vestibular system that is damaged by disease or injury in childhood can have a major impact on a child’s development. In addition, the emergence of vestibular lesions may also lead to cognitive deficits,...

The saphenous venous system was visualized by CT without any contrast medium injection. Volumetric data were acquired with a multidetector spiral CT (Siemens, Somatom Plus 4 Volume Zoom) with the following parameters: collimation, 1 mm; pitch, 4; reconstruction, 1.2 mm. Reformatted images were then transferred in DICOM format to an 02 work station (Silicon Graphics) and postprocessed by the sof...

Mentally challenged individuals are known to have slower speed of reaction. As a previous study has shown immediate improvement in reaction time (RT) following mukha bhastrika, a bellows type of pranayama, we planned to study the effect of this pranayama in mentally challenged adolescents. 34 mentally challenged adolescents (15.1 +/- 0.806 y) studying in a school for Special Needs were recruite...

Although the visual system is known to provide relevant information to guide stair locomotion, there is less understanding of the specific contributions of foveal and peripheral visual field information. The present study investigated the specific role of foveal vision during stair locomotion and ground-stairs transitions by using a dual-task paradigm to influence the ability to rely on foveal ...

The Lower Rio Grande Valley (LRGV) of south Texas is an agriculturally rich area supporting intensive production of vegetables, fruits, grain sorghum, and cotton. Modern agricultural practices involve the combined use of irrigation with the application of large amounts of agrochemicals to maximize crop yields. Intensive agricultural activities in past decades might have caused potential contami...

BACKGROUND Diabetes mellitus is a major risk factor for prolonged hospital stays, renal failure, and mortality in patients having coronary artery bypass grafting (CABG). Complications pose a serious threat to patients and prolong intensive care and hospital stays. Low glomerular filtration rate (GFR) due to existing renal impairment or volume depletion may exacerbate acute renal impairment/fail...