PPARalpha agonists have been characterized largely in terms of their effects on lipids and glucose metabolism, whereas little has been reported about effects on amino acid metabolism. We studied responses to the PPARalpha agonist WY 14,643 (30 micromol x kg(-1) x day(-1) for 4 wk) in rats fed a saturated fat diet. Plasma and urine were analyzed with proton NMR. Plasma amino acids were measured ...

Charles R. Anderson, Jr., Trophy Game Section, Wyoming Game and Fish Department, Lander, WY 82520, USA Keith Aune, Research and Technical Services, Montana Fish, Wildlife and Parks, Helena, MT 59620, USA Kim Barber, U.S. Department of Agriculture, Forest Service, Shoshone National Forest, Cody, WY 82414, USA Dan Bjornlie, Trophy Game Section, Wyoming Game and Fish Department, Lander, WY 82520, ...

1 Robert Kubichek, University of Wyoming, Electrical and Computer Engineering Department, Laramie, WY 82071 [email protected] 2 John Pierre, University of Wyoming, Electrical and Computer Engineering Department, Laramie, WY 82071 [email protected] 3 Frank Tuffner, University of Wyoming, Electrical and Computer Engineering Department, Laramie, WY 82071 4 Jerry Hamann, University of Wyoming, Electr...

Broth MIC and time-kill methodology was used to determine the activity of cefditoren relative to those of penicillin G, ampicillin, amoxycillin, WY-49605, cefuroxime, cefpodoxime, cefdinir, cefixime and cefaclor against three penicillin-susceptible, three intermediate and three penicillin-resistant pneumococci. MICs of all agents rose with those of penicillin G. Cefditoren was the most active a...

The peroxisomal 3-ketoacyl-CoA thiolase B (Thb) gene was previously identified as a direct target gene of PPARalpha, a nuclear hormone receptor activated by hypolipidemic fibrate drugs. To better understand the role of ThB in hepatic lipid metabolism in mice, Sv129 wild-type and Thb null mice were fed or not the selective PPARalpha agonist Wy14,643 (Wy). Here, it is shown that in contrast to so...