Crohn's disease (CD) and ulcerative colitis (UC) make up the so-called chronic inflammatory bowel disease (IBD). Advances in the understanding of IBD pathophysiologic mechanisms in the last few years have allowed the development of novel therapies such as biologic therapies, which at least theoretically represent a more specific management of this disease with fewer side effects. Currently, the...

ardy and Littlewood conjectured that every large integer $n$ that is not a square is the sum of a prime and a square. They believed that the number $mathcal{R}(n)$ of such representations for $n = p+m^2$ is asymptotically given by begin{equation*} mathcal{R}(n) sim frac{sqrt{n}}{log n}prod_{p=3}^{infty}left(1-frac{1}{p-1}left(frac{n}{p}right)right), end{equation*} where $p$ is a prime, $m$ is a...

Like the major vaccinia virus (VV) core protein precursors, p4b and p25K, the 25 kDa VV A12L late gene product (p17K) is proteolytically maturated at the conserved Ala-Gly-Ala motif. However, the association of the precursor and its cleavage product with the core of mature virion suggests that both of the A12L proteins may be required for virus assembly. Here, in order to test the requirement o...

chemokines and their receptors  play an important  role in the  late inflammatory stage of asthma. in this study, we aimed to investigate polymorphisms of mcp-1 (ccl2), ccr2 and ccr5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. mcp-1   (a/g   -2518),  ccr2   (+/64i), ...