The requirement for a safe diagnostic strategy should be based on an overall post-test incidence of venous thromboembolism (VTE) of less than 1% during 3 month follow-up. Compression ultrasonography (CUS) has a negative predictive value (NPV) of 97 to 98% indicating a post-CUS incidence of deep vein thrombosis (DVT) of 2 to 3%. A post-CUS DVT incidence of 3% implicates that 90 to 120 DVTs per 1...

Agmatine is an endogenous neuromodulator that has been shown to have antidepressant-like properties. We have previously demonstrated that it can induce a rapid increase in BDNF levels after acute administration, suggesting that agmatine may be a fast-acting antidepressant. To investigate this hypothesis, the present study evaluated the effects of a single administration of agmatine in mice subj...

BACKGROUND For decades, copper sulphide has been renowned as the superior optical and semiconductor materials. Its potential applications can be ranged from solar cells, lithium-ion batteries, sensors, and catalyst systems. The synthesis methodologies of copper sulphide with different controlled morphology have been widely explored in the literature. Nevertheless, the understanding on the forma...

To integrate photothermal therapy (PTT) with chemotherapy for improving anticancer efficiency, we developed a novel and multifunctional doxorubicin (DOX) conjugated copper sulfide nanoparticle (CuS-DOX NP) drug delivery system using hydrazone bonds to conjugate carboxyl-functionalized copper sulfide nanoparticles (CuS NPs) and DOX. On the other hand, the hydrazone bonds could be used for improv...

In practice, Free Trade Agreements (FTAs) vastly outnumber Customs Unions (CUs). Nevertheless, the literature traditionally views CUs as optimal for members because CU members coordinate external tariffs. I show that a dynamic FTA flexibility benefit can help explain the prevalence of FTAs: individual FTA members have the flexibility to form their own future FTAs whereas CU members must jointly...

Background: Recently, some shocking epidemics of chronic kidney disease of undetermined origin have been reported. In this regard, numerous lines of evidence suggest that socioeconomic and environmental stressors have a key role, an effect that needs further confirmation. The present study was undertaken to explore the effect of Chronic Unpredictable Stress (CUS) on kidney function and structur...

Abstract Purpose To evaluate the incidence and characteristics of brain lesions in moderate-late preterm (MLPT) infants, born at 32–36 weeks’ gestation using cranial ultrasound (cUS) magnetic resonance imaging (MRI). Methods Prospective cohort study carried out Isala Women Children’s Hospital between August 2017 November 2019. cUS was performed postnatal day 3–4 (early-cUS), before discharge re...

Despite efforts in producing nanoparticles with tightly controlled designs and specific physicochemical properties, these can undergo massive nano–bio interactions bioprocessing upon internalization into cells. These transformations generate adverse biological outcomes premature loss of functional efficacy. Hence, understanding the intracellular fate is a necessary prerequisite for their introd...