Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the β-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. It has proved effective in in vivo infection models of Mycobacterium tuberculosis and continues to attract interest as a templat...

A detailed description of the development of the tangent linear model (TLM) and its adjointmodel of the Relaxed Arakawa-Schubert moisture parameterization package used in NASA GEOS-1 C-Grid GCM (Version 5.2) is presented. The notational conventions used in the TLM and its adjoint codes are described in detail. iii

Tree leaf meals (TLM) are increasingly used in the tropics to feed pigs. The nutritive value of the TLM of cocoyam (Xanthosoma saggitifolium), mulberry ( Morus alba) and Trichanthera gigantea, their effect on the digestive tract and their fermentation rate in the large intestine, were determined in adult sows given diets containing 150 or 300 g TLM per kg. The TLM contained from 8·5 to 12·0 MJ ...

With the current trend towards multi-core processors and computer grids, parallelism in system simulation is becoming inevitable. Performing multiple tasks concurrently can save both time and money. However, this also puts higher demands on simulation software. This thesis investigates how simulation-based product development can benefit from distributed simulation. One parallelization method i...

Aufgrund der rasch zunehmenden Komplexität eingebetteter Systeme ergab sich die Notwendigkeit, die Abstraktionsebene im Systementwurf anzuheben. Es wurde die elektronische Systemebene geschaffen, auf der die Systembeschreibungssprache SystemC und die Konzepte zur Modellierung auf Transaktionsebene (engl. Transaction Level Modeling, TLM) große Bedeutung erlangten. TLM-Modelle, die in SystemC ges...

This study aimed to construct a new local pharmacokinetic model of gastrointestinal absorption, the translocation model (TLM), using an anatomically relevant, minimally segmented structure to explain linear and nonlinear intestinal absorption, metabolism, and transport. The TLM was based on the concept of a single absorption site that flexibly moves, expands, and shrinks along with the length o...

A common situation in industry is that a system model (here a composite model) is composed of several submodels which may have been developed using different tools. FMI is one important technology for exporting/importing models between tools and/or connecting them via co-simulation. TLM based modeling and co-simulation is another important technique for modeling, connecting, and simulation of e...

The Transmission Line Matrix ( TLM ) is a physical discretization approach used to solve the wave equation numerically. The method replaces a continuous system by a network or an array of lumped elements. The TLM method involves dividing the solution region into a rectangular mesh of the transmission line segments. The nodes of the mesh are the points of discontinuity for acoustic impedances. A...

A reformulation of the Transmission Line Matrix (TLM) method is presented to model non-dispersive anisotropic media. Two TLM-based solutions solve this problem can already be found in literature, each one with an interesting feature. One considered a more conceptual approach, close TLM fundamentals, which identifies Maxwell’s equations specific line. But simplicity achieved at expense increase ...