Cell surface lipoproteins are important for the full virulence of several bacterial pathogens, including Streptococcus pneumoniae. Processing of prolipoproteins seems to be conserved among different bacterial species, and requires type II signal peptidase (Lsp) mediated cleavage of the N-terminal signal peptide to form the mature lipoprotein. Lsp has been suggested as a target for new antibioti...

The Line Spectrum Pair (LSP) based on the principle of linear predictive coding (LPC) plays a very important role in the speech synthesis; it has many interesting properties. Several famous speech compression / decompression algorithms, including the famous code excited linear predictive coding (CELP), are based on the LSP analysis, where the information loss or predicting errors are often very...

Land surface phenology (LSP) characterizes episodes of greening and browning of the vegetated land surface from remote sensing imagery. LSP is of interest for quantification and monitoring of crop yield, wildfire fuel accumulation, vegetation condition, ecosystem response and resilience to climate variability and change. Deriving LSP represents an effort for end users and existing global produc...

BACKGROUND Yoga and Ayurveda texts emphasize the role of cleansing the bowel as an important component of management of hypertension (HTN). Observations during our clinical experience and pilot studies on Laghu shankha prakshalana kriya (LSP), a yogic bowel cleansing technique, appeared to be safe and complimentary. OBJECTIVE To test the safety and effectiveness of LSP in patients with essent...

"Cluster 9" family lipoproteins function as ligand-binding subunits of ABC-type transporters in maintaining transition metal homeostasis and have been implicated in the virulence of several bacteria. While these proteins share high similarity, the specific metal that they recognize and whether their role in virulence directly involves metal homeostasis cannot be reliably predicted. We examined ...

Localized surface plasmon (LSP) has been widely applied for the enhancement of fluorescence emission for biosensing owing to its potential for strong field enhancement. However, due to its small penetration depth, LSP offers limited fluorescence enhancement over a whole sensor chip and, therefore, insufficient sensitivity for the detection of biomolecules, especially large molecules. We demonst...

Atrial fibrillation (AF) is currently the most common arrhythmia in the world, which is an important contributor to cardiac morbidity and mortality, and classified to five types: first diagnosed AF, paroxysmal AF, persistent AF, long-standing persistent AF (LSP-AF), and permanent AF. LncRNAs, emerging as a novel therapeutic in cardiovascular medicine, attracted widespread attention, although an...

The line spectrum pair (LSP) frequency represer.iation has recent:y been proposed as an alternative linear prediction (LP) parametric representation. In the context of speech coding, this representation shows better quantization properties than the other LP parametric representations. In the present paper, the LSP representation is studied for speech recognition. Several distance measures based...

One desirable application of Bidirectional Forwarding Detection (BFD) is to detect a Multiprotocol Label Switching (MPLS) Label Switched Path (LSP) data plane failure. LSP Ping is an existing mechanism for detecting MPLS data plane failures and for verifying the MPLS LSP data plane against the control plane. BFD can be used for the former, but not for the latter. However, the control plane proc...