نتایج جستجو برای: ژن hoxb13
تعداد نتایج: 15960 فیلتر نتایج به سال:
Optimal selection of endocrine therapy for women with estrogen receptor–positive breast cancer will require biomarkers with better positive predictive value than the current immunohistochemical assay. There has been great interest to employ genomic technology to identify the subset of women with estrogen receptor–positive breast cancers who benefit from hormonal agents, and from those studies w...
BACKGROUND A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer. In a family-based analysis by The International Consortium for Prostate Cancer Genetics (ICPCG), the G84E mutation was most prevalent in families from the Nordic countries of Finland (22.4%) and Sweden (8.2%). METHODS To further investigate the importance of G84E in the Finns, ...
Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried out a systematic literature search using the Pubmed service of the National Cen...
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