Results RCTs provide evidence for rilonacept and canakinumab in CAPS, colchicine in FMF and (adeno)tonsillectomy in PFAPA syndrome. For Behçet disease, RCTs have been conducted on the effect of several drugs, including colchicine, azathioprine, cyclosporine A, interferon alfa, etanercept, sucralfate suspension and pimecrolimus. Descriptive studies suggest that NSAIDs and corticosteroids are hig...

The conceptual understanding of museums as ‘contact zones’ has been widely appropriated in the museum literature and beyond. But the discussion lacks empirical insights into actual experiences: What does ‘contact’ mean for the person experiencing it? How is it lived, negotiated and contested? Drawing on a long-term narrative study of global visitors to the Museum of New Zealand Te Papa Tongarew...

Prions are important disease agents and epigenetic regulatory elements. Prion formation involves the structural conversion of proteins from a soluble form into an insoluble amyloid form. In many cases, this structural conversion is driven by a glutamine/asparagine (Q/N)-rich prion-forming domain. However, our understanding of the sequence requirements for prion formation and propagation by Q/N-...

The present study investigates the clinical applicability of a new device, which objectively measured nasal resonating vibration via piezoelectric vibratory sensor in 10 normal volunteers, 10 patients with definite hypernasality, and 10 nasal polyposis patients. For the assessment of the hypernasality, the ratio of /ng/ to /a/ as well as the ratio of /mama/ to /papa/ passages were used. For the...

We show that the classical algebra of quaternions is a commutative Z2×Z2×Z2-graded algebra. A similar interpretation of the algebra of octonions is impossible. This note is our “private investigation” of what really happened on the 16th of October, 1843 on the Brougham Bridge when Sir William Rowan Hamilton engraved on a stone his fundamental relations: i = j = k = i · j · k = −1. Since then, t...

Introduction Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is an autosomal dominant autoinflammatory disease caused by mutations in the proline-serinethreonine phosphatase-interacting protein 1, PSTPIP1. The produced protein is a cytoskeleton-associated adaptor protein that modulates T-cell activation, cytoskeletal organization and IL-1b release. The only two mutations desc...

An aperture composed of multiple small apertures has several advantages over a large continuous aperture when practical issues are included in the analysis. For example, a single bullet can easily produce a catastrophic failure of the laser communication link if all the optical gain for the transmitter (or receiver) is derived from a single large-diameter telescope. In addition to battlefield c...

Resumo Objetivo Traduzir e adaptar transculturalmente, para uso no Brasil, a Parental Perception on Antibiotics Scale (PAPA Scale) avaliar confiabilidade da versão em português. Métodos Estudo metodológico tradução adaptação transcultural PAPA Scale, desenvolvido seis etapas, que abrangem inicial, síntese tradução, de volta língua original (back-translation), revisão por um comitê sete especial...