Small nuclear ribonucleoproteins (snRNPs) represent key constituents of major and minor spliceosomes. snRNPs contain a common core, composed of seven Sm proteins bound to snRNA, which forms in a step-wise and factor-mediated reaction. The assembly chaperone pICln initially mediates the formation of an otherwise unstable pentameric Sm protein unit. This so-called 6S complex docks subsequently on...

Photoassociation of ultracold atoms induced by chirped picosecond pulses is analyzed in a nonperturbative treatment by following the wavepackets dynamics on the ground and excited surfaces. The initial state is described by a Boltzmann distribution of continuum scattering states. The chosen example is photoassociation of cesium atoms at temperature T=54 μK from the aΣ u (6s, 6s) continuum to bo...

A series of 5-carbomethoxybenzoxazole derivatives (6a-t) were prepared by using methyl-p-hydroxybenzoate. The identity of the compounds was confirmed on the basis of their elemental analysis and spectral data. In anti-MES test compounds 6b, 6d, 6h, 6j, 6m, 6p, 6q and 6s showed potent activity parallel to lipophilicity. Compounds 6b, 6d, 6k, 6n and 6s successfully passed the rotorod test without...

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This paper is on efficient implementation techniques of Elliptic Curve Cryptography. In particular, we improve timings for Jacobiquartic (3M+4S) and Hessian (7M+1S or 3M+6S) doubling operations. We provide a faster mixed-addition (7M+3S+1d) on modified Jacobiquartic coordinates. We introduce tripling formulae for Jacobi-quartic (4M+11S+2d), Jacobi-intersection (4M+10S+5d or 7M+7S+3d), Edwards (...

We develop two schemes for tuning the scattering length on the ground triplet state of Cs 2. First, an absolute value of the triplet scattering length of 133 Cs 2 is determined using the experimental data (Fioretti et al, Eur.Phys.J. 5, 389 (1999)). Then, we demonstrate that the large scattering length can be made small and positive by coupling of the 3 Σ + u (6S + 6S) potential to the 3 Π g st...

Heparan sulphate (HS), a ubiquitously expressed glycosaminoglycan (GAG), regulates multiple cellular functions by mediating interactions between numerous growth factors and their cell surface cognate receptors. However, the structural specificity of HS in these interactions remains largely undefined. Here, we used completely synthetic, structurally defined, alternating N-sulfated glucosamine (N...

Smooth muscle myosin filaments formed in 0.15 M KCl are depolymerized by MgATP to a 10S component, rather than to the 6S component typical of myosin monomer in high salt concentrations. This 10S species is also monomeric as determined by sedimentation equilibrium and calculated from the diffusion and sedimentation coefficients. The conformation of 10S myosin is, however, very different from tha...

The reflectance of the Earth's surface is significantly influenced by atmospheric conditions such as water vapor content and aerosols. Particularly, the absorption and scattering effects become stronger when the target features are non-bright objects, such as in aqueous or vegetated areas. For any remote-sensing approach, atmospheric correction is thus required to minimize those effects and to ...

This paper is on efficient implementation techniques of Elliptic Curve Cryptography. We improve group operation timings for Hessian and Jacobi-intersection forms of elliptic curves. In this study, traditional coordinates of these forms are modified to speed up the addition operations. For the completeness of our study, we also recall the modified Jacobiquartic coordinates which benefits from si...