The next step beyond third generation mobile networks is the Third Generation Partnership Project standard, named Long Term Evolution. A key feature of Long Term Evolution is the enhancement of multimedia broadcast and multicast services (MBMS), where the same content is transmitted to multiple users located in a specific service area. To support efficient download and streaming delivery, the T...

BACKGROUND The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that controls cell growth and proliferation via the translation regulators eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S...

The numerical solution of the Linearized Boltzmann Equation (LBE) via the Discrete Ordinates method (SN) requires extensive computational resources for large 3-D neutron and gamma transport applications due to the concurrent discretization of the angular, spatial, and energy domains. This paper will discuss the development RAPTOR-M3G (RApid Parallel Transport Of Radiation – Multiple 3D Geometri...

mTORC1 is a critical regulator of cell growth that integrates multiple signals and is deregulated in cancer. We previously reported that mTORC1 regulation by hypoxia involves Redd1 and the Tsc1/Tsc2 complex. Here we show that Redd1 induction by hypoxia is tissue dependent and that hypoxia signals are relayed to mTORC1 through different pathways in a tissue-specific manner. In the liver, Redd1 i...

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract This document describes a Fully-Specified Forward Er...

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract This document describes a Fully-Specified Forward Er...

This paper proposes a fountain coding system which has lower space decoding complexity and lower decoding erasure rate than the Raptor coding systems. The main idea of the proposed fountain code is employing shift and exclusive OR to generate the output packets. This technique is known as the zigzag decodable code, which is efficiently decoded by the zigzag decoder. In other words, we propose a...

The mammalian target of rapamycin (mTOR) controls cell growth in response to amino acids and growth factors, in part by regulating p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor (regulatory associated protein of mTOR) is a 150 kDa mTOR binding protein that is essential for TOR signaling in vivo and also binds 4EBP1 and p70alpha through thei...

The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR axis, although treatment resistance is a major problem. Here, we aimed to understand how RCC cells acquire resistance to PI3K-mTOR inhibition. We used the RCC4 cell line to generate a model of in vitro resistance by continuous culture in PI3K...

Multimedia Broadcast/Multicast Services (MBMS) have been introduced by Third Generation Partnership Project (3GPP) aiming to efficiently deliver data to mobile users in a one-to-many way. In order to provide reliable multicast transmission, 3GPP recommends exclusively for MBMS the use of a Forward Error Correction (FEC) mechanism on the application layer. Raptor codes are standardized as the Ap...