نتایج جستجو برای: گیرنده شبه toll 9
تعداد نتایج: 520525 فیلتر نتایج به سال:
Abbreviation: HIV-1: Human Immunodeficiency Virus Type 1; CHI: Chronic HIV-1 Infection; PDCs: Plasmacytoid Dendritic Cells; IFN-α: Interferon-α; TLR: Toll-like Receptor; TLR7: Toll-like Receptor 7; TLR9: Toll-like receptor 9; IRF7: Interferon Regulatory Factor 7; NF-κB: Nuclear factor κB; NCs: Normal Controls; MSM: Men Who Have Sex With Man; PBMC: Peripheral Blood Mononuclear Cells; ICS: Intrac...
Toll-like receptor 9 (TLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. To prevent autoimmune responses, Toll-like receptor 9 is excluded from the cell surface and silenced until the N-terminal half of the ectodomain (TLR9N) is cleaved off in the endolysosome. Truncated Toll-like receptor 9 (TLR9C) senses ingested microbial DNA, alth...
Persistent infection by high-risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.
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