Purpose: Genomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with non-small cell lung adenocarcinoma (NSCLC) were ascertained and correlated with clinical characteristics and therapeutic outcomes.Experimental Design: Comprehensive plasma ctDNA testing was performed in 88 consecutive patients; 34 also had tissue next-generation sequencing; 29, other forms of genotypi...

Using a set of heterogeneous competing systems with intra-system cooperation and inter-system unfair competition, we show how the coevolution of the system parameters (degree of cooperation and unfair competition) depends on the external supply of resources. This kind of interaction is found in social, economic, ecological and biochemical systems; as an illustration we consider the competition ...

IMPORTANCE Advantages of caffeine for apnea of prematurity have prompted clinicians to use it prophylactically even before apnea. OBJECTIVE To determine the effect of early initiation of caffeine therapy on neonatal outcomes in very preterm infants born in Canada. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study was conducted. Patients included preterm neonates born at less th...

Predicting peptide binding affinity with human leukocyte antigen (HLA) is a crucial step in developing powerful antitumor vaccine for cancer immunotherapy. Currently available methods work quite well in predicting peptide binding affinity with HLA alleles such as HLA-A*0201, HLA-A*0101, and HLA-B*0702 in terms of sensitivity and specificity. However, quite a few types of HLA alleles that are pr...

BACKGROUND Control of modifiable cardiovascular disease (CVD) risk factors has substantially reduced CVD mortality, but risk factor levels in populations may change and need continuous monitoring. This study aims to provide current estimates of the prevalence of these risk factors in Germany according to sex and history of coronary heart disease (CHD) or stroke. METHODS The analyses were base...

We present new Spitzer Space Telescope observations of stars in the young (∼5 Myr) γ Velorum stellar cluster. Combining optical and 2MASS photometry, we have selected 579 stars as candidate members of the cluster. With the addition of the Spitzer mid-infrared data, we have identified 5 debris disks around A-type stars, and 5-6 debris disks around solar-type stars, indicating that the strong rad...

BACKGROUND Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein inhibitors in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Co...

AIM To examine whether self-reported treatments, workplace-oriented rehabilitation and change of occupation were associated with subsequent sickness absence and disability pension among long-term sick-listed for psychiatric disorders. DESIGN A prospective cohort study. SETTING AND PARTICIPANTS 5200 employees (80% from the Swedish municipalities and county councils and 20% manual workers fro...

We report here on the photometric and kinematic properties of a well defined group of nearly 200 low-mass pre-main sequence stars, concentrated within ∼ 1 of the early-B star 25 Ori, in the Orion OB1a sub-association. We refer to this stellar aggregate as the 25 Orionis group. The group also harbors the Herbig Ae/Be star V346 Ori and a dozen other early type stars with photometry, parallaxes, a...

BACKGROUND Racial disparities in care are well documented; information regarding solutions is limited. We evaluated whether generic quality improvement efforts were associated with changes in racial disparities in diabetes care. METHODS Using insurance claims and electronic medical record data, we identified 5101 whites and 1987 blacks with diabetes mellitus receiving care within a multispeci...