The purpose of these studies was to test whether 02 tension influences cardiotoxicity due to doxorubicin. Isolated hearts were perfused by the method of Langendorff at constant pressure with Krebs-Henseleit buffer saturated with 5% CO2 and either 95% or 20% 02. Toxicity due to doxorubicin was evaluated from changes in heart rate and from uptake of trypan blue by nonviable nuclei. Heart rate was...

BACKGROUND The effect of increased arterial stiffness on mitral regurgitation (MR) is not clear. Using wave intensity (WI) analysis, which is useful for analyzing ventriculo-arterial interaction, we aimed to elucidate associations of increased arterial stiffness with left ventricular (LV) ejection performance and right ventricular systolic pressure (RVSP) in MR. METHODS AND RESULTS We noninva...

In this paper, we mainly study the convergence properties of stochastic gradient descent (SGD) as described in Needell et al. [2]. The function to be minimized with SGD is assumed to be strongly convex. Also, its gradients are assumed to be Lipschitz continuous. First, we discuss the superior bound on convergence (of standard SGD) obtained by Needell et al. [2] as opposed to the previous work o...

mycophenolic acid is a secondary extracellular metabolite of penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. the aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by penicillium brevi-compactum atcc16024 was investigated. batch submerged fer...

Understanding of cell cycle regulation in hormonally responsive cells lags behind studies in other systems because few models have been available to identify the role of steroid hormones and their receptors in this process. This study investigates progesterone-dependent effects on the progression of normal uterine stromal cells through early G1 phase of the cell cycle. Quiescent rat uterine str...

Medroxyprogesterone acetate (MPA) is a synthetic progestin commonly used in hormone replacement therapy (HRT). The aim of this research was to study and compare the effect of progesterone (Pg) and MPA on the regulation of cellular events associated with vascular homeostasis and disease. Platelet adhesion to endothelial cells (ECs), nitric oxide (NO) production, and cell migration were studied u...

Sustainable construction aims to reduce the negative environmental impact of buildings throughout their life cycle, which includes design, construction, use, demolition and recycling. Taking into account successive stages concrete cycle elements sustainable need carry out research analysis properties with additives was noticed in aspects e.g., production stage, its durability during operation p...

Introduction: One of the most important complications of exposure to noises is changes in the gene expression patterns. Irreversible damage to the inner ear, such as noise-induced hearing loss (NIHL), is caused by tissue damage and changes in the gene expressions in the auditory system. Changes in the GJB2 gene expression pattern lead to autosomal deafness at different loci. The present study a...

We investigate the W∞ algebra in the integer quantum Hall effects. Defining the simplest vacuum, the Dirac sea, we evaluate the central extension for this algebra. A new algebra which contains the central extension is called the W1+∞ algebra. We show that this W1+∞ algebra is an origin of the KacMoody algebra which determines the behavior of edge states of the system. We discuss the relation be...

The tissue-specific Wilms‘ tumor gene W1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the W1 gene in 4 of 36 acute leukemias. W1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise...