نتایج جستجو برای: 0290 and 0301
تعداد نتایج: 16827229 فیلتر نتایج به سال:
A new method of sequential extraction of proteins followed by quantitative and qualitative determination by reverse-phased high-performance liquid chromatography (RP-HPLC) was used to analyse the effect of environmental conditions (3N fertilisation rates, two varieties, two sites and two growing seasons) on quantitative and qualitative variation of wheat storage proteins. The results showed tha...
OBJECTIVE In the oligoarticular subgroup of juvenile idiopathic arthritis, a strong association has been found with the expression of human leukocyte antigen class II molecules HLA-DQA1 *0401-DQB1*0402 and DQA1*0501-DQB1*0301, whereas DQA1*0501-DQB1*0201 is neutral and DQA1 *0201-DQB1*0201 protective. A presentation of different peptides by these DQ alleles would support their role in the disea...
To the Editor—In a recent article, Thio et al. [1] sought to determine whether DQB1*0301 and other HLA class II alleles were associated with hepatitis C virus (HCV) clearance and persistence in 3 multiethnic cohorts. The results of their analyses confirmed the previously documented association of DQB1*0301 and other HLA class II alleles with viral clearance [2]. Furthermore, Thio et al. hypothe...
The term “phenotype,” first coined by the Danish botanist Wilhelm Johannsen in 1909, is defined as “the observable characteristics of an individual resulting from the interaction of its genotype with the environment.” The success in mapping complex disease genes and in identifying genotype and environment interactions depends on how well the phenotype is defined. Complex diseases such as sarcoi...
OBJECTIVE To study HLA class II association in reactive arthritis. METHODS 63 patients with reactive arthritis and 46 with rheumatoid arthritis were included in the study. HLA-DR alleles were determined by using a sequence specific PCR method. Oligonucleotide hybridisation was used for definition of DRB1*04 subtypes and DQB1 alleles. HLA-B27 was determined by standard microcytotoxity test or ...
The association of narcolepsy with HLA-DQB1*0602 is established in Japanese, African-Americans, European, and North American Caucasians. We examined DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 in 163 patients with centrally mediated daytime sleepiness (100 with narcolepsy) and 211 Korean controls. In this population, the DQB1*0602 association was always evident in the context of the DRB1*1501-DQA1*0...
Abstract Background In Crohn’s disease (CD) Smad7 is overexpressed in the intestinal mucosa, where it contributes to a sustained production of inflammatory cytokines, increased matrix metalloproteinase (MMP) activity and chronic inflammation through inhibition anti-inflammatory actions TGF-beta. GED-0301, an anti-sense oligodeoxynucleaotide complementary mRNA Smad7, inhibits translation synthes...
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