Tertiary piperazine aminoalcohols were synthesized by reacting 1-(4-butoxyphenyl)-3-(4-substituted piperazin-1-yl)-2-phenylpropan-1-ones with alkyl(aryl)magnesium halides. Some of the final compounds converted into dihydrochlorides. The influence on C-180 mouse tumor DNA methylation was studied in vitro incubating drug solutions (3 × 10–6 M) homogenates at 37°C (thermostatted) for 24 h. Rather ...