Both presynaptic and postsynaptic dopaminergic functions can be estimated by positron emission tomography (PET). While both presynaptic and postsynaptic dopaminergic functions would be regulated by corresponding genes and related to personality traits, the relation between presynaptic and postsynaptic functions in terms of interindividual variation has hardly been investigated. In the present s...

UNLABELLED (18)F-BCPP-EF was applied to assess mitochondrial complex I (MC-I) activity in the brains of Parkinson disease model monkeys prepared by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and also presynaptic dopamine parameters. METHODS (11)C-β-CFT for the dopamine transporter; (11)C-3,4-dihydroxy-phenyl-L-alanine (β-(11)C-L-DOPA), L-6-(18)F-fluorodopa ((18)F-FDOPA), or 6-(11)C-m...

In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy...

Objective: Boswellic acids (BAs) are active constituents of plant Boswellia serrata. In the present study boswellic acids were extracted from Boswellia serrata and dry methanolic extracts were quantified by HPLC and HPTLC. Method: A gradient HPLC method was used for the quantification of the boswellic acids; 11-keto-β-boswellic acid (KBA) and 3acetyl-11-keto-β-boswellic acid (AKBA). A direct HP...

Biocoatings were formed on the surface of Mg0.8Ca alloy by method micro-arc oxidation, in an electrolyte containing β-Ca3(PO4)2 (β-TCP) and CaSiO3, When process voltage was varied range 350–500 V, thickness, roughness, mass coatings increased to values 110 µm, 12 11 mg, respectively. The presence following crystalline phases determined coatings: α-TCP, wollastonite, forsterite magnesium oxide. ...

We consider the potential detection of chameleons using bouncing ultracold neutrons. We show that the presence of a chameleon field over a planar plate would alter the energy levels of ultracold neutrons in the terrestrial gravitational field. When chameleons are strongly coupled to nuclear matter, β≳10(8), we find that the shift in energy levels would be detectable with the forthcoming GRANIT ...

Background: Approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. This study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia. Methods: Fifteen compound heterozygous sickle cell thalassemia (SCT) and 23 β-thalassemia trait patients were st...

Alzheimer's disease is a multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation and neurodegeneration, where the interrelationships between the different pathophysiological events are not yet well characterized. In this study, longitudinal multitracer positron emission tomography imaging of individuals with autosomal dominant or sporadic Alzheimer's ...

UNLABELLED Abnormal glutamate transmission is involved in various neurologic disorders, such as epilepsy, schizophrenia, and Parkinson disease. At present, no imaging techniques are capable of measuring acute fluctuations in endogenous glutamate levels in vivo. We evaluated the potential of (11)C-ABP688, a PET ligand that binds to an allosteric site of the metabotropic glutamate 5 receptor, in ...

and Applied Analysis 3 (C6) (P + JQN)γ(∂Ω 2 ) ⊂ C, (C7) Ψ γ (Ω 2 \ Ω 1 ) ⊂ C, then the equation Lx = Nx has a solution in the set C ∩ (Ω 2 \ Ω 1 ). 3. Positive Solution for the Nonresonant Problem In this section, we suppose that f ∈ C([0, 1] × [0, +∞), [0, +∞)) and ∑m−2 i=1 β i < 1. We begin with some preliminary results. Consider the problem x 󸀠󸀠󸀠 (t) + y (t) = 0, t ∈ [0, 1] , (10) x 󸀠󸀠 (0) =...