N-Aryl-S,S-dimethylsulfimides 3(Ar = 4-NO(2)C(6)H(4)), 4 (Ar = Ph) and 5 (Ar = 4-Tol)react with Appel salt 1 to give the corresponding N-aryl-(4-chloro-5H-1,2,3-dithiazolylidene)benzenamines 8 (Ar = 4-NO(2)C(6)H(4)), 9 (Ar = Ph) and 10 (Ar = 4-Tol) in 84, 94 and 87% yields, respectively. The reaction proceeds in the absence of base and a proposed reaction mechanism is given.

Cobalt(II) diaryl complexes react with CO to afford Co(2)(CO)(8) and sterically encumbered ketones whose structure varies depending on the nature of the aryl ligands.

5'-4-Alkyl/aryl-1H-1,2,3-triazole derivatives PILAB 1-12 were synthesized and a pharmacological screening of these derivatives was performed to identify a possible effect on the Central Nervous System (CNS) and to explore the associated mechanisms of action. The mice received a peritoneal injection (100 µmol/kg) of each of the 12 PILAB derivatives 10 min prior to the injection of pentobarbital ...

Anthocyanins as natural pigments are colorful and environmentally compatible dyes for dye-sensitized solar cells (DSSCs). To increase the efficiency, we designed and synthesized unnatural O-methylflavonols and O-methylcyanidins that possess an aryl group at the 8-position. We synthesized per-O-methylquercetin from quercetin, then using selective demethylation prepared various O-methylquercetins...

A direct oxidative cross-dehydrogenative coupling (CDC) of N-aryl tetrahydroisoquinolins with 5H-oxazol-4-ones catalyzed by CuBr using air as the only oxidant has been developed, which could also proceed smoothly under a metal-free oxidative system with PhI(OAc)2 as the oxidant. A series of alkylated tetrahydroisoquinolin derivatives were obtained in good yields and excellent diastereoselectivi...

BackgroundTapinarof cream is a topical therapeutic aryl hydrocarbon receptor modulating agent under investigation for treatment of psoriasis and atopic dermatitis.MethodsIn phase 2b, double-blind, vehicle-controlled study, adults with plaque were randomized to tapinarof 0.5% or 1% once twice daily vehicle 12 weeks 4-week follow-up. Efficacy outcomes included Physician Global Assessment (PGA) sc...

brønsted acidic ionic liquid triethylamine-bonded sulfonic acid {[et3n-so3h]cl} efficiently catalyzes the one-pot multi-component condensation of 2-naphthol with arylaldehydes and dimedone (5,5-dimethylcyclohexane-1,3-dione) under solvent-free conditions to afford 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in high yields and relatively short reaction times.