The colorectal cancer ranks high among the malignant tumours in incidence and mortality and irinotecan is standardly used in palliative treatment of metastatic disease in every therapeutic line. Unfortunately, the treatment with irinotecan is often associated with severe toxicities, especially neutropenia and diarrhea. The majority of the toxic manifestation is caused by the insufficient deacti...

Background: The presence of several risk factors (genetic and non-genetic) has greater impact on the risk of premature coronary artery disease (CAD) than single risk factor. Objective: The aim of the study was to establish possible relations between genotypes and alleles of 677C>T polymorphism of MTHFR gene and some traditional risk factors e.g. elevated levels of lipid parameters and smoking i...

Front cover by Guozhong Gao et al: High-precision bolt length detection and rapid evaluation of anchoring quality through Hilbert transient spectrum analysis. https://doi.org/10.1002/eng2.12581

Calculations of the nuclear modification factor, R dAu , for π 0 production in dAu collisions at √ s N N = 200 GeV are presented. The applied pQCD-improved parton model incorporates intrinsic k T. Nuclear multiscattering and nuclear shadowing are considered in the Au nucleus. Theoretical results are displayed for midrapidity and high pseudorapidity, η, and compared to preliminary PHENIX and BRA...