The aim of the present study is to investigate the influence of the environmental factors, smoking and alcohol, on the biotransformation of cyclophosphamide (CP) in the rat in vivo and in vitro with S9 liver fractions. The biotransformation of CP was studied by the determination of the CP metabolites, nor-nitrogen mustard (NNM), 4-ketocyclophosphamide (KCP), and carboxyphosphamide (CAR). The ef...

Clostridium difficile infection (CDI) is associated with increased cost, morbidity, and mortality in postoperative patients. Variable rates of postoperative CDI are reported among 4 surgical specialties during the 30-month study period. Risk factors for CDI include antibiotic use, increased ASA score, and increased admissions in the past year. Infect Control Hosp Epidemiol 2017;38:1254-1257.

ion. Submitted for publication, Sept. 1998. Available at http://www.csl.sri.com/ ̃singermn/ integration.html.[8] H. Saı̈di and S. Graf. Construction of abstract state graphs with PVS. In O. Grumberg, editor, Computer-Aided Verification, CAV ’97, volume 1254 of Lecture Notes in Computer Science, pages 72–83, Haifa, Israel, June 1997. Springer-

The nervous system is dependent upon thyroid hormones for normal development, and we previously reported that developmental Aroclor 1254 (A1254) exposure caused hypothyroxinemia, hearing loss and other behavioral changes in rats. (Goldey et al., 1995a; Herr et al., 1996). The hypothesis that A1254-induced hypothyroxinemia may have contributed to the observed functional changes was tested in pri...

Although polychlorinated biphenyls (PCBs) have been banned in many countries for more than three decades, exposures to PCBs continue to be of concern due to their long half-lives and carcinogenic effects. In National Institute for Occupational Safety and Health studies, we are using semiquantitative plant-specific job exposure matrices (JEMs) to estimate historical PCB exposures for workers (n ...

Polychlorinated biphenyls (PCBs) decrease thyroid function in laboratory rodents by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (UDP-GT), thereby increasing thyroxine (T4) clearance. This loss of T4 can lead to hypothyroidism. In this study, an assay was validated for measuring UDP-GT activity toward T4 in Japanese quail. UDP-GT induction by Aroclor 1254 was...

Address correspondence and reprint requests to: Dr. Wen-Chao Song Institute for Translational Medicine and Therapeutics and Department of Pharmacology University of Pennsylvania School of Medicine, Rm 1254 BRBII/III, 421 Curie Blvd Philadelphia, PA 19104, Tel: 215-573-6641, Fax: 215-746-8941 [email protected] Blood First Edition Paper, prepublished online June 4, 2008; DOI 10.1182/bloo...

Correspondence to Maha Abdellatif, M.B.ChB, PhD and Danish Sayed, MD, PhD Cardiovascular Research Institute Department of Cell Biology and Molecular Medicine University of Medicine and Dentistry of New Jersey 185 S Orange Ave, Newark, NJ 07103. Maha Abdellatif Tel: (973) 972-1254 Fax: (973) 972-7489 E-mail: [email protected] Danish Sayed Tel: (973) 972-1208 Fax: (973) 972-7489 E-mail: s...

Previous studies have revealed that one of the major metabolites of PCBs detected in human blood, 4-OH-2,3,3',4',5-pentaCB (4-OH-CB107), accumulated in fetal liver, brain, and plasma and reduced maternal and fetal thyroid hormone levels after prenatal exposure to pregnant rats from gestational days (GD) 10-16. In the present study, the effects of 4-OH-CB-107 on developmental landmarks, steroid ...