BACKGROUND Our study aimed to assess the prognostic value of poorly differentiated clusters (PDCs) in invasive breast cancer. METHODS A total of 146 cases of operable invasive ductal carcinoma that was not otherwise specified (IDC-NOS), from 2002 to 2009, were pathologically reviewed. Cancer clusters with five or more cancer cells and lacking gland-like structures were counted from a field co...

To maintain genome stability during fluctuating environmental conditions, cells have adapted mechanisms to regulate cell cycle events. For unicellular organisms, such as budding yeast, this response is essential for the survival of the organism. For example, under conditions of nutrient limitation, diploid budding yeast cells enter meiosis and package the meiotic products into spores. The spore...

Aim: In our study, we aimed to reveal the effect of tumor budding(TB) on prognosis in urothelial carcinomas and compare most commonly used alternative method (AM) International Tumor Budding Consensus Conference (ITBCC) system. TB can be easily assessed routine hematoxylin eosin-stained slides. studies, was found associated with prognostic parameters many organs. assessment organ cancers is bas...

Quiescence is a ubiquitous cell cycle stage conserved from microbes through humans and is essential to normal cellular function and response to changing environmental conditions. We recently reported a massive repressive event associated with quiescence in Saccharomyces cerevisiae, where Rpd3 establishes repressive chromatin structure that drives transcriptional shutoff [6]. Here, we describe i...