نتایج جستجو برای: 137 سرب
تعداد نتایج: 18551 فیلتر نتایج به سال:
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes. In the present study, we identified miR-137 as a potential regulator of CtBP1 expression in melanoma cells. Expression of miR-137 in melanoma cell lines was found to inversely correlate with CtBP1 levels. Target Scan predicted a putative site for miR-137 wit...
________________________________________ Introduction __ ___________________________________ Area covered.__________________________________ Aeromagnetic survey.___________________________ Gravity survey.________________________________ Acknowledgments--.. __1________________________ Geology __ __ ____________ _ Rock units_____________________________________ Carboniferous and older rocks._____...
The molecular mechanisms underlying colorectal cancer (CRC) development remain elusive. In this study, we examined the miRNA and mRNA expressions in the adenoma-carcinoma sequence (ACS), a critical neoplastic progression in CRC development. We found that miR-137 was down-regulated in all adenoma and carcinoma tissues. Low miR-137 levels were correlated negatively with tumor progression and meta...
سزیم-137 رادیو نوکلوئیدی مصنوعی با نیمه عمر 30/2 سال و تشعشع گاما است که به دلیل انفجارهای هسته ای در دهه 1950 و 1960 همراه با بارش باران وارد جو زمین شد. این عنصر به سرعت جذب ذرات ریز افق سطحی خاک می شود و توزیع آن اصولا با تحولات فیزیکی خاک نظیر فرسایش و شخم همراه است. اساس محاسبه فرسایش به روش سزیم رادیواکتیو بر مبنای مقایسه مقدار سزیم در خاک در معرض فرسایش با یک سطح مرجع می باشد. مقادیر نسب...
BACKGROUND/AIMS Demonstrating the molecular mechanisms of human adipose tissue-derived mesenchymal stem cells (hADSCs) differentiation and proliferation could develop hADSCs-based cell therapy. METHODS The microRNA-137 (miR-137) and cell division control protein 42 homolog (CDC42) levels were regulated by oligonucleotides transfection. The adipogenic differentiation was induced for 10 days in...
OBJECTIVE MiR-137 has been reported to serve as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the potential mechanism remains largely unclear. The present study aimed to explore the potential molecular mechanisms by which miR-137 regulated NSCLC. MATERIALS AND METHODS Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to quantify the expressio...
PURPOSE Ketamine is commonly used in pediatric anesthesia but may cause neurodegeneration in young brains. The aim of the study is to use an animal model to characterize the role of microRNA 137 (miR-137) in ketamine-induced neurodegeneration in neonatal hippocampus. METHODS Young Sprague-Dawley Rats (1 month old) was systemically administrated with ketamine (75 mg/kg) for 3 days. TUNEL assay...
در این تحقیق، ابتدا با اضافه کردن مقادیر متفاوتی از افزودنیهای تیتانیا و زیرکونیا به یکی از ترکیبات اصلی که در اینکار مورد مطالعه قرار گرفته است، نمونه هائی (مطابق جدول 2-2) ساخته شدند. بهینه مقدار افزودنیها، در افزایش مقاومت به خوردگی نمونه های مختلف شیشه ای، با نگهداری این نمونه ها در زمان ثابت 65 ساعت درون محلول اسید نیتریک نیم نرمال، تعیین شد. سپس ترکیبات مختلف شیشه سربی، از (5/55 تا 5/68) ...
OBJECTIVES To characterize a novel CTX-M chimera, CTX-M-137, from Escherichia coli clinical isolates in China. METHODS Isolates were collected from five hospitals between 22 February 2009 and 20 December 2011. Resistance genes were investigated by PCR. blaCTX-M-137 was cloned and purified for kinetic measurements. Conjugation experiments, S1-PFGE and Southern blotting were performed to study ...
Glioblastomas (GBM), the most common and aggressive malignant astrocytic tumors, contain a small subpopulation of cancer stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence. Here, we study the expression and function of miR-137, a putative suppressor miRNA, in GBM and GSCs. We found that the expression of miR-137 was significantly lower in GBM and GSCs compared ...
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