In this work, the role of HDAC6, a type II histone deacetylase with tubulin deacetylase activity, in lymphocyte polarity, motility, and transmigration was explored. HDAC6 was localized at dynamic subcellular structures as leading lamellipodia and the uropod in migrating T-cells. However, HDAC6 activity did not appear to be involved in the polarity of migrating lymphocytes. Overexpression of HDA...

Candida albicans is an important pathogenic fungus of humans, causing a range of infections. These infections are usually treated with antifungal drugs that target sterol metabolism. Resistance to these antifungals can result from overexpression of sterol biosynthetic genes. Therefore it is of interest to understand transcriptional regulation of sterol biosynthesis in C. albicans. Recently two ...

Vol. 26, No. 6, 2014 789 Received November 14, 2013, Revised February 25, 2014, Accepted for publication March 14, 2014 Corresponding author: Hyun Jeong Park, Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea. Tel: 82-2-3779-1391, Fax: 82-2-783-7604, E-mail: hjpark@ catholic.ac.kr This i...

Ethylene oxide was tested on groups of rats for either 4-hour or 1-hour inhalation exposure, followed by 14 days of observation. Groups of five Sprague-Dawley rats/sex were exposed, and clinical signs and mortality were recorded. Clinical signs noted included irregular breathing, absence of certain reflexes, and tremors. Rats that died had moderate to severe pulmonary congestion. The calculated...

Studies by Urbanowski et al. [Urbanowski, M. L., Stauffer, L. T., Plamann, L. S. & Stauffer, G. V. (1987) J. Bacteriol. 169, 1391-1397] have identified a regulatory locus, called metR, required for the expression of the metE and metH genes. We recently purified the MetR protein from Escherichia coli and showed that it could stimulate the in vitro expression of the metE gene and autoregulate its...

Yuan Fang, Ge Sun,* Peter Caldwell, Steven G. McNulty, Asko Noormets, Jean-Christophe Domec, John King, Zhiqiang Zhang, Xudong Zhang, Guanghui Lin, Guangsheng Zhou, Jingfeng Xiao and Jiquan Chen 1 Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, USA 2 Eastern Forest Environmental Threat Assessment Center, Southern Research Station, USDA Forest Se...

554 Ann Dermatol Received October 25, 2010, Revised November 10, 2010, Accepted for publication November 10, 2010 *This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (20110001390) and Basic research program through the NRF funded by the Ministry of Education, Science and Technology (2010-0002431). Corresponding author: Hyun Jeo...

Poland syndrome is characterized by unilateral absence or hypoplasia of the pectoralis muscle and variable degree of ipsilateral hand anomalies. Möbius syndrome is a congenital neurological disorder characterized by complete or partial facial paralysis. Although the pathogeneses of these diseases are not well-characterized, diminished blood flow to the affected side is thought to play a role. A...

We examine the adoption of patient care IT systems by US short-term acute care hospitals and the resulting impact these systems have in the productivity of hospitals. Of particular interest is the extent to which forprofit and non-profit hospitals obtain different results from the adoption of IT systems. We find that the marginal effect of IT on for-profit hospital productivity is to reduce the...