نتایج جستجو برای: 153sm edtmp
تعداد نتایج: 189 فیلتر نتایج به سال:
The recently reported amphiphilic chelate, [Gd(EPTPAC16)(H2O)]2-, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect of sonication on the aggregate size was characterized by dynamic light scattering and relaxometry, indicating the presence of premicellar aggregates a...
background: the formalism recommended by task group 60 (tg-60) of the american association of physicists in medicine (aapm) is applicable for β sources. radioactive biocompatible and biodegradable 153sm glass seed without encapsulation is a β- emitter with a short half life and delivers a high dose rate to the tumor in the millimeter range. in this work the dosimetry parameters of the seed for ...
Background: The 153Sm-[tris(1,10-phenanthroline) Samarium(III)]complex (153Sm-PL3) was prepared in view of development of targeting therapeutic compounds for malignancies, and interesting in-vitro anti-tumor activities of lanthanide phenanthroline complexes,. Materials and Methods: Sm-153 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of enriched 152Sm2O3 sample, diss...
introduction: in continuation of recent development of possible c-x-c chemokine receptor type 4 (cxcr4) imaging agents, we report the development of a possible cxcr4 targeted therapy agent. methods: [153sm]labeled 1,1′-[1,4-phenylenebis(methylene)] bis-1,4,8,11-tetraazacyclo -tetradecane ([153sm]-amd3100) was prepared using [153sm]smcl3 and amd-3100 for 24h at 50°c in acetate buffer.stability ...
Phosphonic acids labeled with beta-emitting radionuclides are promising radiopharmaceutical drugs for palliative therapy of bone metastases. Currently, the possibility using a new osteotropic compound N,N,N’,N’-ethylenediaminetetrakis (methylene phosphonic acid) lutetium-177 (177Lu-EDTMP) is being studied. The aim work to develop compartment mathematical model kinetics 177Lu in body laboratory ...
introduction compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. in this study, we aimed to develop a pharmacokinetic model of 153sm-maltolate complex as a novel therapeutic agent and...
Metastatic disease to bone is commonly seen in the advanced stages of many cancers. The cardinal symptom, pain, is often the cause of significant morbidity and reduced quality of life. Treatment of bone pain includes nonsteroidal analgesics and opiates; however, long-term use of these drugs is commonly associated with significant side effects, and tolerance is common. External-beam radiation th...
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