Nevière, R. R., M. L. Pitt-Hyde, R. D. Piper, W. J. Sibbald, and R. F. Potter. Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G933–G940, 1999.—Our major objective was to investigate whether injury to the mucosa of the small intestine occurred in a normotensive model of sepsis and whether such inju...

BACKGROUND Delayed diagnosis and treatment of newborn infection adversely impact outcomes. Clinical laboratory parameters have aimed to obtain the most correct and prompt diagnosis and treatment of this disease. This study simultaneously observed changes over time in APR as well as proinflammatory cytokines and anti-proinflammatory cytokines and aims to clarify usefulness of APR scores. METHO...

BACKGROUND Clinical trials have demonstrated the effectiveness of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) for reducing HIV acquisition. Understanding how HIV care providers are prescribing PrEP is necessary to ensure success of this prevention strategy. METHODS During 2013-2014, we surveyed US HIV care providers who also provided care to HIV-negative patients. We es...

Two classes of genes are used for breeding rust resistant wheat. The first class, called R (for resistance) genes, are pathogen race specific in their action, effective at all plant growth stages and probably mostly encode immune receptors of the nucleotide binding leucine rich repeat (NB-LRR) class. The second class is called adult plant resistance genes (APR) because resistance is usually fun...

CONTEXT Solubility limitation of BCS class II drugs pose challenges to in vitro release. OBJECTIVE To investigate the miscibility of Aprepitant (APR) and Soluplus(®) (SOL) for hot melt extrusion (HME) viability and improved in vitro release of APR. METHODS Solubility parameters of APR and SOL from group contribution methods were evaluated. Heat-cool-heat differential scanning calorimetry (D...

The objective of the present study was to analyze the effect of a mixture of medicinal plants [Angelica gigas Nakai, Panax ginseng and Rhus verniciflua Stokes (APR)] on lipopolysaccharide (LPS)-induced inflammatory responses in the murine macrophage cell line RAW264.7. Cells were treated with APR and LPS at various concentrations and indicated times. WST assay, trypan blue assay and quantificat...

Ricci, Anthony J., and Manning J. Correia. Electrical response properties of avian lagena type II hair cells: a model system for vestibular filtering. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R943–R953, 1999.—Data presented represent the first electrical recordings from avian lagena type II hair cells. The perforated-patch variant of the whole cell recording technique was...

Takala, Teemu O., Pirjo Nuutila, Juhani Knuuti, Matti Luotolahti, and Hannele Yki-Järvinen. Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E706–E711, 1999.—There are no studies comparing myocardial metabolism between enduranceand resistance-trained athletes. We used 2-deoxy-2-[18F]fluoro-Dglucose ...

Jones, Stephen C., Carol R. Radinsky, Anthony J. Furlan, Douglas Chyatte, and Alejandro D. PerezTrepichio. Cortical NOS inhibition raises the lower limit of cerebral blood flow-arterial pressure autoregulation. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1253–H1262, 1999.— The maintenance of constant cerebral blood flow (CBF) as arterial blood pressure is reduced, commonly referred to as CB...

UTA ECKHARDT,1 ALICE SCHROEDER,1 BRUNO STIEGER,1 MATHIAS HÖCHLI,2 LUKAS LANDMANN,3 RONALD TYNES,4 PETER J. MEIER,1 AND BRUNO HAGENBUCH1 1Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich; 2Central Laboratory for Electron Microscopy, University of Zurich, CH-8028 Zurich; 3Department of Anatomy, University of Basel, CH-4000 Basel; and 4D...