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Loss-of -function mutations in human ether-a-go-go-related gene 1 (hERG1) is associated with life-threatening arrhythmias. hERG1 activators are being developed as treatments for acquired or genetic forms of long QT syndrome. The locations of the putative binding pockets for activators are still being elucidated. In silico docking of the activator 1,3-bis-(2-hydroxy-5-trifluoromethylphenyl)-urea...
lactic acid bacteria (lab) are gram positive and non- spore forming bacteria that can produce some special substances for growth inhibition of pathogenic, non-pathogenic and food spoilage bacteria. the aim of this study was to determine the inhibitory effects of lactobacillus acidophilus ptcc1643 (dsm 20079) and lactobacillus plantarum ptcc 1058 (atcc 8014) cultural supernatants against urinary...
Abstract Stellar positions and velocities from Gaia are yielding a new view of open cluster dispersal. Here we present an analysis group stars spanning Cepheus ( l = 100°) to Hercules 40°), hereafter the Cep-Her complex. The includes four Kepler objects interest: Kepler-1643 b R p 2.32 ± 0.13 ⊕ , P 5.3 days), KOI-7368 2.22 0.12 6.8 KOI-7913 Ab 2.34 0.18 24.2 Kepler-1627 3.85 0.11 7.2 days). lat...
The efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptotheci n (irinotecan, CPT-11) has been examined against a panel of six independently derived neuroblastoma xenografts. Intensive courses of therapy, where irinotecan was administered i.v. daily 5 days per week for two consecutive weeks [(dx5)2; defined as 1 cycle], were compared to more pro...
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