The purpose of this note is to posit and discuss the concept of "competitive inhibition potential" (CIP), which is an in vivo index of the ability of a competitive inhibitor to elevate plasma concentrations of drug substrates, when the competitive inhibitor is administered at its usual and customary dose.

Quantitative scaling into percent signal change is helpful to detect and eliminate “bad” results with abnormal extreme values. While cognitive effects give signal changes on the order of 1% (and larger in the visual and auditory cortices), signal variations of over 10% may arise from motion and other artifacts in the data. Thus, a quantitative check on measured effect size can be used to screen...

BACKGROUND Widespread use of herbal medications/supplements among the presurgical population may have a negative effect on perioperative patient care. Thus, the authors' goal was to identify the prevalence of such use in a cosmetic surgery patient population compared with use among the general public; to assess physician awareness of proper management of these herbal medications/supplements; an...

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OBJECTIVE The authors studied the clinical outcomes of suicidal adolescents who were treated within a rapid-response outpatient model in a setting in which a ten-day wait was usually required before outpatient treatment could be started, leaving hospitalization as the only immediately available alternative. METHODS A total of 286 suicidal adolescents aged 12 to 17 years who came to the emerge...