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ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Modrzyński R, Pisarska A, Mańkowska AM. The Hazardous Use Scale of psychoactive substances. A pilot study. Alcoholism and Drug Addiction/Alkoholizm i Narkomania. 2022;35(3):187-204. doi:10.5114/ain.2022.125279. APA Modrzyński, R., Pisarska, A., & Mańkowska, A. M. (2022). Narkomania, 35(3), 187-204. https://doi.org...
The $g$-factor and static quadrupole moment of the nuclides $^{135}$Pr, $^{105}$Pd, $^{187}$Au in wobbling motion are investigated particle-rotor model as functions total spin $I$. $^{105}\mathrm{Pd}$ increases with increasing $I$, due to negative gyromagnetic ratio a neutron valence-neutron. This behavior is contrast decreasing other two nuclides, $^{135}$Pr $^{187}$Au, which feature valence-p...
Although the Abelson (Abl) tyrosine kinase inhibitor imatinib mesylate has improved the treatment of breakpoint cluster region–Abl (Bcr-Abl)–positive leukemia, resistance is often reported in patients with advanced-stage disease. Although several Src inhibitors are more effective than imatinib and simultaneously inhibit Lyn, whose overexpression is associated with imatinib resistance, these inh...
BACKGROUND Detection of cytologic atypia in nipple aspirate fluid (NAF) has been shown to be a predictor of risk for development of breast carcinoma. Manual collection of NAF for cytologic evaluation varies widely in terms of efficacy, ease of use, and patient acceptance. We investigated a new automated device for the non-invasive collection of NAF in the office setting. METHODS A multi-cente...
BACKGROUND Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise the cytotoxicity and DNA damage induced by the bisdioxopiperazine ICRF-187 by a combination of genetic...
Timing of progression of Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study BMC Infectious Diseases 2012, 12:187 doi:10.1186/1471-2334-12-187 Sereina A Herzog ([email protected]}) Christian L Althaus ([email protected]}) Janneke C M Heijne ([email protected]}) Pippa Oakeshott ([email protected]}) Sally Kerry ([email protected]}) P...
This study aimed to explore the role of aberrant miRNA expression in epilepsy and to identify more potential genes associated with epileptogenesis.The miRNA expression profile of GSE49850, which included 20 samples from the rat epileptic dentate gyrus at 7, 14, 30, and 90 days after electrical stimulation and 20 additional samples from sham time-matched controls, was downloaded from the Gene Ex...
The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas. p27 can be phosphorylated on threonine 187 by Cdks, and cyclin E/Cdk2 overexpression can stimulate the degradation of wild-type p27, but not of a threonine 187-to-...
BACKGROUND The urine lipoarabinomannan (LAM) strip-test (Determine®-TB) can rapidly rule-in TB in HIV-infected persons with advanced immunosuppression. However, given high rates of empiric treatment amongst hospitalised patients in high-burden settings (≈ 50%) it is unclear whether LAM can add any value to clinical decision making, or identify a subset of patients with unfavourable outcomes tha...
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