A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) test. The activity experimental study showed that 2,2-dipropyl-N¹-(4-...

The cis-dibromination of unsaturated bicyclic bridgehead sultams 5a and 5b, and experiments designed to understand the cis-stereochemical outcome of these reactions, are described. In the case of 5b, a novel solvent dependent carbocation rearrangement occurs with the formation of 18b. cis-Dibromides 13a and 13b undergo regioselective dehydrobromination, and the participation of the resultant vi...

Abstract The metastable helium line at 1083 nm can be used to probe the extended upper atmospheres of close-in exoplanets and thus provide insight into their atmospheric mass loss, which is likely significant in sculpting population. We an ultra-narrow band filter centered on this observe two transits low-density gas giant HAT-P-18b, using 200? Hale Telescope Palomar Observatory, report detecti...

Hygromycin was first reported in 19531,2) and several identical antibiotics such as homomycin and 1703-18B have been described.3, 4,5) Although the structure of the antibiotic was determined by chemical degradations,6,7,8) some structural aspects must still be resolved. First, neoinosamine-2 is known to be a constituent with a methylene substitution, whose location, however, has not been defini...

Drosophila N-cadherin is required for the formation of precise patterns of connections in the fly brain. Alternative splicing is predicted to give rise to 12 N-cadherin isoforms. We identified an N-cadherin allele, N-cad(18Astop), that eliminates the six isoforms containing alternative exon 18A and demonstrate that it strongly disrupts the connections of R7 photoreceptor neurons. During the fir...

In this study, it was aimed to determine the antagonistic effect between and isolated from eggplant roots some root bacteria conditions. 24 were soil samples taken rhizosphere regions of infected non-infected plants in different production areas 22 them evaluated as candidate biocontrol agents. According results research, 13 out effective against, 14 9 against 40% 100%. The most 22B (100%) 11B ...

The title compound, K(0.8)Ca(9.8)Fe(0.2)(PO(4))(7) (potassium deca-calcium iron hepta-phosphate), belongs to the whitlockite family. The structure is built up from several types of metal-oxygen polyhedra: two [CaO(8)], one [CaO(7)] and one [(Ca/Fe)O(6)] polyhedron with a mixed Ca/Fe occupancy in a 0.8:0.2 ratio, as well as three tetra-hedral [PO(4)] units. Of the 18 sites in the asymmetric unit...