The purpose of this study is to investigate the potential use of Ir-192 as the source for real time imaging during HDR (High Dose Rate) brachytherapy treatment. Phantom measurement was performed to determine outside of the body dose. Monte Carlo code, EGSnrcMP egs_inprz, was used for the simulation to calculate the outside of the body x-ray signal for CT reconstruction. Matlab code was develope...

Although both radiotherapy and surgery can cure the majority of patients with early oral tongue cancer, radiotherapy consisting mainly of interstitial brachytherapy has the advantage of preserving the tongue function. Interstitial brachytherapy alone employing iridium-192 hairpins or wires has been the standard radiotherapy during the past few years for localised early oral tongue cancer at the...

Epidermal clonogenic cell survival and colony formation following irradiation were investigated and related to radiosensitivity. A rapid in vivo/in vitro assay was developed for the quantification of colonies arising from surviving clonogenic cells in pig epidermis after irradiation. Bromodeoxyuridine (BrdU)-labelled cells in full thickness epidermal sheets were visualized using standard immuno...

conclusions according to the findings of this study, the most common cause of penetrating neck injuries was stab wounds, and the majority of patients were young men, therefore, preventive measures should be implemented. because of fatal complications associated with neck injuries, we recommend early neck exploration in unstable cases or when injuries are deeper than the platysma. results among ...

BACKGROUND Intracavitary irradiation plays a pivotal role in definitive radiotherapy for cervical cancer, and the Ir-192 high dose-rate remote afterloading system (HDR-RALS) is often used for this purpose. Under this condition, tumor tissues receive remarkably different absorption doses, with a steep gradient, depending on distance from the radiation source. To obtain temporo-spatial informatio...

AIM To examine the efficacy of major radioactive sources used in brachytherapy and the influence of age. PATIENTS AND METHODS Six hundred and forty-eight patients with node negative oral tongue cancer (T1-3NOMO; 212T1, 352T2, 84T3) treated at Osaka University Hospital, between 1967 and 1999, were reviewed. RESULTS The 5-year local control rates for patients treated with Ra-226 and Ir-192 we...

Key features of diabetic nephropathy (DN) include the accumulation of extracellular matrix proteins such as collagen 1-alpha 1 and -2 (Col1a1 and -2). Transforming growth factor beta1 (TGF-beta), a key regulator of these extracellular matrix genes, is increased in mesangial cells (MC) in DN. By microarray profiling, we noted that TGF-beta increased Col1a2 mRNA in mouse MC (MMC) but also decreas...