T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, cell compartment includes different subsets, and their dysregulation following anti-checkpoint therapy can lead to the development of adverse events. The aim this study was evaluate activation markers – homeostatic cytokine transcription factor...

A motion detection algorithm, based on biological and computational models, for focal plane implementation has been developed. This Temporal Domain Optical Flow Measurement (TDOFM) algorithm uses computational components which have direct and compact electronic counterparts. It uses a binary image of zero-crossings, 2 level analog signals, the signs of spatiotemporal derivatives, 1-b multiplica...

To improve spatial resolution, PET systems are being developed with finer detector elements. Unfortunately, using smaller crystal sizes increases inter-crystal Compton scatter and bismuth x-ray and (to a lesser degree) electron escape crosstalk, causing positioning errors that lead to degradation of image contrast. We investigated the use of extremely thin (I 300 ym) lead strips for passive shi...

To improve spatial resolution, positron emission tomography (PET) systems are being developed with finer detector elements. Unfortunately, using a smaller crystal size increases intercrystal Compton scatter and X-ray escape crosstalk, causing positioning errors that can lead to degradation of image contrast. We investigated the use of extremely thin ( 300 m) lead strips for passive shielding of...

We calculate partition functions for lens spaces Lp,q up to p = 8 and for genus 1 and 2 handlebodies H1, H2 in the Turaev-Viro framework. These can be interpreted as transition amplitudes in 3D quantum gravity. In the case of lens spaces Lp,q these are vacuum-to-vacuum amplitudes Ø → Ø, whereas for the 1and 2-handlebodies H1, H2 they represent genuinely topological transition amplitudes Ø → T 2...

� Ensure reproducibility of the clean-up procedure Properly purified PCR products are crucial for many molecular biological applications. When a large number of different products are required the purification procedure has to deal with many samples in parallel. Moreover, it needs to be fast and reliable. Authors: Dr. Thomas Zinn 1and Dr. Martin Gajewski 2 1 MACHEREY-NAGEL GmbH & Co. KG, Neuman...

In this paper we study relations which are congruences with respect to ∧ and ⊔p, where ⊔pis the p-cut of the L-fuzzy hyperoperation ⊔. The main idea is to start from an equivalence relation R1 which is a congruence with respect to ∧ and ⊔1and, for each p ∈ X , construct an equivalence relation Rp which is a congruence with respect to ∧ and ⊔p. Furthermore, for each x ∈ Rp we construct a quotien...

Storage of 42° Brix Pineapple and Valencia orange concentrates at 40° F. resulted in in creased gelation, clarification, and apparent pulp content, whereas pectin decreased. Total glycosides, as hesperidin, remained constant in these products during storage. The experi mental packs heated at 1and 2-fold were more stable than those heated at 3and 4fold; also all of the Valencia concentrates, con...