نتایج جستجو برای: 1b

تعداد نتایج: 23152  

1998
Michael K. Hansen James M. Krueger

There is considerable interest in the mechanisms by which systemic cytokines signal the CNS to elicit centrally controlled biological actions. This study determined the effects of intraperitoneal injections of interleukin-1b (IL-1b) on IL-1b mRNA and IL-1 receptor accessory protein (IL-1RAP) mRNA production in rat liver and brain using the reverse transcription-PCR. Saline or IL-1b (0.5 mg/kg) ...

Journal: :The Journal of Cell Biology 1993
F Balzac A M Belkin V E Koteliansky Y V Balabanov F Altruda L Silengo G Tarone

We have previously described a variant form of the integrin beta 1 subunit (beta 1B)1 characterized by an altered sequence at the cytoplasmic domain. Using polyclonal antibodies to a synthetic peptide corresponding to the unique sequence of the beta 1B, we analyzed the expression of this molecule in human tissues and cultured cells. Western blot analysis showed that the beta 1B is expressed in ...

Journal: :hepatitis monthly 0
farah bokharaei-salim department of virology, iran university of medical sciences, tehran, ir iran; hiv laboratory of national center, deputy of health, iran university of medical sciences, tehran, ir iran mostafa salehi-vaziri department of arboviruses and viral hemorrhagic fevers (national ref lab), pasteur institute of iran, tehran, ir iran farzin sadeghi cellular and molecular biology research center, health research institute, babol university of medical sciences, babol, ir iran maryam esghaei department of virology, iran university of medical sciences, tehran, ir iran seyed hamidreza monavari department of virology, iran university of medical sciences, tehran, ir iran seyed moayed alavian middle east liver disease center, tehran, ir iran; iran hepatitis network, tehran, ir iran

background the hepatitis c virus (hcv) infection has been identified as a leading cause of progressive liver diseases worldwide. despite new treatment strategies, pegylated interferon alfa-2a (peg-ifnα-2a), in combination with ribavirin (rbv), still represents the gold standard of therapy for hepatitis c in developing countries. results in this study, a significant association was observed betw...

Journal: :Molecular and cellular biology 2000
L D Klaman O Boss O D Peroni J K Kim J L Martino J M Zabolotny N Moghal M Lubkin Y B Kim A H Sharpe A Stricker-Krongrad G I Shulman B G Neel B B Kahn

Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the role of PTP-1B in vivo, we generated homozygotic PTP-1B-null mice by targeted gene disruption. PTP-1B-deficient mice have remarkably low adiposity and are protected from diet-induced ob...

Journal: :Neuron 2011
Lu Chen Ya Fu Min Ren Bing Xiao Charles S. Rubin

RasGRPs, which load GTP onto Ras and Rap1, are expressed in vertebrate and invertebrate neurons. The functions, regulation, and mechanisms of action of neuronal RasGRPs are unknown. Here, we show how C. elegans RGEF-1b, a prototypical neuronal RasGRP, regulates a critical behavior. Chemotaxis to volatile odorants was disrupted in RGEF-1b-deficient (rgef-1⁻/⁻) animals and wild-type animals expre...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Evita van de Steeg Anita van Esch Els Wagenaar Cornelia M M van der Kruijssen Olaf van Tellingen Kathryn E Kenworthy Alfred H Schinkel

PURPOSE Organic anion-transporting polypeptides (OATP) mediate the cellular uptake of a broad range of drugs. The hydrophobic anticancer drug, paclitaxel (PTX), was recently identified as a substrate for OATP1B3 in vitro. We investigated the role of Oatp1a/1b transporters in the pharmacokinetics of PTX in vivo, as well as their impact at different dose levels of PTX and methotrexate (MTX). EX...

2000
Quan He Margot C. LaPointe

We have shown that interleukin-1b (IL-1b) activates the human brain natriuretic peptide (hBNP) promoter via a transcriptional mechanism. Others have reported that changes in intracellular calcium (Ca) mediate the action of IL-1b. We questioned whether Ca and Ca-dependent pathways mediate IL-1b regulation of the hBNP promoter in cardiac myocytes. The hBNP promoter (21818 to 1100) coupled to a lu...

2011
Francesca Bagnato

Recombinant interferon beta-1b (IFNβ-1b) was the first approved disease-modifying therapy for patients with multiple sclerosis (MS) by the world regulatory agencies for medical drugs and devices. IFNβ-1b significantly decreases the inflammatory component of MS but still has doubtable effect on the neurodegenerative component. This article appraises the beneficial effects of IFNβ-1b on clinical ...

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