BACKGROUND Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compo...

Extremely accurate and precise quantitative NMR was demonstrated using the new qNMR tools in VnmrJ 3.1 software and calibration with an external standard. Periodic calibration can deliver accuracy as high as 99.9 % and precision as good as 0.59%, while performing calibration with each study can result in accuracy and precision as high as 100% and 0.35%, respectively.

Extremely accurate and precise quantitative NMR was demonstrated using the new qNMR tools in VnmrJ 3.1 software and calibration with an external standard. Periodic calibration can deliver accuracy as high as 99.9 % and precision as good as 0.59%, while performing calibration with each study can result in accuracy and precision as high as 100% and 0.35%, respectively.

LIDIA S. SZCZEPANIAK,1,2 EVELYN E. BABCOCK,3 FRITZ SCHICK,4 ROBERT L. DOBBINS,1,2 ABHIMANYU GARG,2 DENNIS K. BURNS,5 J. DENIS MCGARRY,1,2,6 AND DANIEL T. STEIN1,2 1Center for Diabetes Research, Departments of 2Internal Medicine, 3Radiology, 5Pathology, and 6Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235; and 4Department of Radiology, University of Tübingen, 7...

BACKGROUND The objective of this study was to evaluate the efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the detection of prostate cancer. MATERIALS AND METHODS The experimental group consisted of 20 patients with localized prostate cancer who underwent radical prostatectomy. The sensitivity, positive predictive value and accuracy of the detection of prostate cancer in the 12...

The assignment of the aliphatic 1H and 13C resonances of IL-1 beta, a protein of 153 residues and molecular mass 17.4 kDa, is presented by use of a number of novel three-dimensional (3D) heteronuclear NMR experiments which rely on large heteronuclear one-bond J couplings to transfer magnetization and establish through-bond connectivities. These 3D NMR experiments circumvent problems traditional...

New organotin substituted alpha-anilinomethylphosphonates were prepared and were characterized by FT-IR, 1H- and 13C-NMR spectroscopy and elemental microanalysis.

This study aimed to use an existing ligand (imidazole)-assisted 1H-nuclear magnetic resonance (1H-NMR) spectroscopy protocol determine sulfate content of seaweed sulfated saccharides. Twenty samples – spanning nine species and multiple geographic locations were analyzed. Extracts obtained by immersing freeze-dried seaweeds in boiling water, followed alginate precipitation. Remaining supernatant...

Eight novel 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized in order to obtain new compounds with potential anti-nociceptive and anti-inflammatory activity. The titled compounds were synthesized by the condensation of 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzotriazole (2) and appropriate acid chlorides. Compound 2 was synthesized by reacting 3-(1H-benzo[d][1,...