We describe a gas-liquid chromatographic (GC) method for determination of oxybuprocaine, and a gas chromatographic-mass spectrometric (GC-MS) method for simultaneous determination of four of its nine metabolites in urine. We used an Extrelut column to simply and rapidly extract oxybuprocaine and its metabolites from urine. For the GC-MS analyses, we monitored the characteristic fragment ions at...

The literature on alcaptonuria has been well summarized (1--6). Paschkis et al. (7) reported that thiouracil and para-aminobenzoic acid inhibited the in vitro conversion of tyrosine to melanin by tryrosinase, and White (8) found that thiouracil inhibited melanuria. Lerner and associates (9) noted that the tyrosinase of mouse melanoma is a copper protein whose activity can be inhibited by the ad...

OBJECTIVES Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. MATERIALS AND METHODS In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-a...

Lincomycin (863 units per mg), acetylsalicylic (13, >98%), 3-aminobenzoic (15, 98%), 4-amino-2chlorobenzoic (22, 97%), 4-amino-2-hydroxybenzoic (26, 99%), benzoic (6, >97%), 2-chlorobenzoic (8, 98%), trans-cinnamic (44, 99%), 4-coumaric (43, 98%), 2,3-dichlorobenzoic (40, 97%), 2,5-dichlorobenzoic (36, 97%), 3,4-dichlorobenzoic (31, 99%), 3,4-dihydroxybenzoic (30, 97%), 3,4-dimethoxybenzoic (32...

A series of aminobenzoic acid crystals with stacking-induced emission properties has been achieved and the packing structures of the hydrogen-bonded acid dimers provided an explanation for the emission characteristics of the crystals.

Two human acetyl-CoA:arylamine N-acetyltransferases (NAT1 and NAT2) have been identified. Therapeutic and carcinogenic agents that are substrates for these isoenzymes (including isoniazid, sulfamethazine, p-aminobenzoic acid, 5-aminosalicyclic acid, and 2-aminofluorene) have been used to evaluate the role of the N-acetylation polymorphisms of NAT1 and NAT2 in the treatment of disease and differ...

We report on nanoindentation data for two pairs of polymorphic compounds p-aminobenzoic acid (pABA) and p-nitrobenzoic (pNBA) compare it with existing in the literature. also explore a new parameter, s-PBC, as tool to estimate hardness.

The occurrence of many of the water-soluble vitamins in sweat has been reported in recent years. Sargent, Robinson, and Johnson (1) have reviewed the literature on the occurrence of ascorbic acid, dehydroascorbic acid, thiamine, riboflavin, pantothenic acid, and nicotinic acid in sweat. We have demonstrated the presence of pyridoxine and its metabolites (2), choline (3), N1-methylnicotinamide (...