The concept of conservation of amino acids is widely used to identify important alignment positions of orthologs. The assumption is that important amino acid residues will be conserved in the protein family during the evolutionary process. For paralog alignment, on the other hand, the opposite concept can be used to identify residues that are responsible for specificity. Assuming that the funct...

The recent neutrino data seem to favor two large and one small mixing angles and a hierarchy of their squared mass differences. We discuss these within the context of hierarchical neutrino masses. We show that this scheme suggests a specific neutrino mass matrix with mild fine-tuning. We then present a Froggatt-Nielsen model that reproduces this matrix. e-mail: [email protected] e-mail: ramon...