An octahedral ruthenium(II) Schiff base complexes of the type [Ru(CO)(Py)L] (L = dianion of the Schiff bases derived from acetoacetanilide with o-phenylenediamine and salicylaldehyde/ohydroxyacetophenone/o-vanillin/2-hydroxy-1-naphthaldehyde) have been synthesized from the reactions of equimolar ratio of [Ru(CO)(PPh3)2(Py)] and Schiff bases in benzene. The formation of the Schiff base ligands a...

The symmetrical tetra-dentate Schiff base complexes were prepared by the reaction of 2-hydroxy naphthaldehyde and 1,8-diaminonaphthalene in 2:1 molar ratio. The ligand and its complexes with Cu(II), Ni(II), Mn(II) and Zn(II) ions were characterized by elemental analysis, molar conductance, infrared, electronic spectra, cyclic voltammetry, thermal, Magnetic and EPR studies. Furthermore, antibact...

Activities of two principal cytosolic forms of human aldehyde dehydrogenase, ALDH1A1 and ALDH3AI in colon tumor homogenates and surrounding tissue fragments were measured, using isozymeselective, fluorimetric assays. The assays are based on two fluorogenic substrates, 6-methoxy-2-naphthaldehyde and 7-methoxy-l-naphthaldehyde, and are independent of NADH determinations. The results show high var...

Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The IRE1α-XBP1 pathway, a key branch of the UPR, is activated in many cancers. Here, we show that the expression of both mature and spliced forms of XBP1 (XBP1s) is up-regulated in acute myeloid leukemia (AML) cell lin...

In the mononuclear title compound, [Cu(II)(C(18)H(12)N(2)O(2))(C(5)H(5)N)], the Cu(II) ion is coordinated by two O atoms and one N atom from the dianionic tridentate L(2-) ligand (H(2)L is 2-hy-droxy-1-naphthaldehyde benzoyl-hydrazide) and one N atom from a pyridine mol-ecule in a CuN(2)O(2) distorted square-planar coordination environment.