The oncogene hypothesis postulates that mutated cellular genes, termed proto-onc genes, function as cancer genes because they are related to retroviral onc genes. However, in contrast to retroviral onc genes, mutated proto-onc genes from cancers are not sufficient for carcinogenesis. Therefore, it has been proposed that mutated proto-onc genes depend on other proto-onc genes for carcinogenesis....

It is often claimed that Kripke (1980) and Putnam (1975) established that many predicates, most importantly natural kind predicates, are like proper names in being rigid designators. This insight is generally regarded as having important consequences in the theory of necessary truths: the rigidity of terms such as 'Hesperus', 'Phosphorus', 'water' and 'H 2 O' is used in explaining why identity ...

This paper puts forward a new division of the history Germanic languages, taking into account existence three different historical periods (prehistoric, proto-historic, and literary) in development from Common or Proto-Germanic to modern analogously Romance Romanic languages Vulgar Latin (also called Proto-Romanic Proto-Romance), which stages can be retraced: (prehistoric), (proto-historic) lit...

The article deals with the original Eastern Romance vocabulary recorded in dialects of Ukrainian language and its proto-forms, as well examines formation semantics borrowings from Proto-Indo- European period to present. To achieve goal, author compiles a corpus words presented dialects, determines their Indo- European, Italic Latin corrects those them indicated etymological literature, establis...

The Late Neogene witnessed various major paleoceanographic changes that culminated in intense Northern Hemisphere Glaciation (NHG). The cause and effects of these changes are still debated. We use a multiproxy approach to determine the relative timing of the closure of the Panama gateway, changes in Atlantic circulation, global cooling and ice sheet growth. Benthic foraminiferal Mg/Ca records f...

It has been an interesting question that why there are one-third of Kuiper Belt Objects (KBOs) trapped into the 3:2 resonance but, in contrast, only several KBOs are claimed to be associated with the 2:1 resonance. In a model proposed by Zhou et al. (2002), the stochastic outward migration of the Neptune could reduce the number of particles in the 2:1 resonance and thus the objects in the 3:2 r...

Background & Objective: The current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. The study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. Patients and Methods: A total of 86 cases, 33 colorectal adenomas, 33 colorect...