the affinity of low density lipoprotein(ldl) to its receptor is very important, because most of ldl-uptake pathway is done by the ldl receptor and the change in size of ldl particle and the modification in its components may affect the ldl affinity for its receptor. in this study, the effects of a powerful lipid-soluble antioxidant “ubiquinol-10” have been investigated on the affinity of ldl to...

introduction: nucleus cuneiformis (ncf), as part of descending pain inhibitory system, cooperates with periaqueductal gray (pag) and rostral ventromedial medulla (rvm) in supraspinal modulation of pain. cannabinoids have analgesic effects in the pag, rvm and ncf. the transient receptor potential vanilloid type 1(trpv1) can be activated by anandamide and win55,212-2 as a cannabinoid receptor ago...

conclusions this study suggests that decrease in levels of tlr3 and tlr7 expression is a mechanism that may enable hcv to evade the host innate immune response. results in both groups, we had 13 males and 12 females with a mean age of 48.7 ± 16. tlr3 (6.23 ± 0.91 vs. 3.89 ± 0.85, p < 0.001) and tlr7 (1.48 ± 0.82 vs-1.33 ± 1.18, p < 0.001) expressions were significantly lower in patients with ch...

introduction: previous studies have indicated that stress levels of glucocorticoid hormones induce impairment of long term memory retrieval, but the underlying mechanisms (genomic or non-genomic) are not clear. to clarify this issue, we investigated the involvement of brain corticosteroid receptors and protein synthesis in the glucocorticoid-induced impairment of memory retrieval. methods: 140 ...

conclusions anesthesiologists need to be aware of dextromethorphan’s clinical pharmacology because recreational abuse of the drug has become increasingly common in adolescents and young adults. case presentation a 30-year-old man with a history of a nasal fracture was scheduled to undergo an elective septorhinoplasty. he reported daily consumption of large quantities (1440 to 1800 mg) of dextro...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...