STUDY OBJECTIVES Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy. METHODS A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had either a concu...

OBJECTIVES To assess the effect of periodic and moderate alcohol intake on gallbladder motility. METHODS The ultrasonographic ellipsoid method was used in 21 healthy male subjects: 12 non-alcohol and 9 alcohol drinkers. The stimulus for gallbladder contraction was 165 ml of half cream milk. Gallbladder dynamics were studied for 20 minutes following the ingestion of the milk. The mean percenta...

CONTEXT Heavy consumption of alcohol can lead to heart failure, but the relationship between moderate alcohol consumption and risk of heart failure is largely unknown. OBJECTIVE To determine whether moderate alcohol consumption predicts heart failure risk among older persons, independent of the association of moderate alcohol consumption with lower risk of myocardial infarction (MI). DESIGN...

We describe a 73 year-old patient with mitral valve pericardial bioprosthesis Carpentier-Edwards 29M implanted due to the rheumatic mitral stenosis 21 years ago. Hemodynamic destabilisation had emerged 18 months before the admission. Echocardiography revealed significant bioprosthesis degeneration with calcification of its leaflets, small pannus on the bioprosthetic ring, moderate mitral stenos...

BACKGROUND Accelerated coronary atherosclerosis is a major factor limiting allograft longevity in cardiac transplant recipients. Histopathology studies have demonstrated the insensitivity of coronary angiography for detecting early atheromatous disease in this patient population. Intracoronary ultrasound is a new imaging technique that provides characterization of vessel wall morphology. The pu...

OBJECTIVE To quantify incidence, age distribution, and seasonality of neonatal hypothermia among a large population cohort. DESIGN Longitudinal cohort study. SETTING Sarlahi, Nepal. PARTICIPANTS A total of 23 240 newborns born between September 2, 2002, and February 1, 2006. Main Exposures Community-based workers recorded axillary temperature on days 1 through 4, 6, 8, 10, 12, 14, 21, and...

Pulps removed from a series of 21 crown-fractured incisors, which had been treated by partial pulpotomy and which had been clinically judged as healed 12 to 95 months (mean 52 months) after treatment, were examined histologically. In five pulps a few, scattered lymphocytes were seen, and in one pulp there was a slight infiltration with lymphocytes and a few plasma cells. In 10 pulps calcificati...

OBJECTIVES Long-term safety and tolerability of ACC-001 (vanutide cridificar), an antiamyloid- beta therapeutic vaccine, was evaluated in subjects with mild to moderate Alzheimer's disease. DESIGN Phase 2a extension studies of randomized parent trials were conducted in the United States, European Union, and Japan. METHODS Four immunizations of ACC-001 were administered at the same 3 dose le...

Purpose: This study examined the 6-month prevalence of depression and suicidal probability among new referrals to an adolescent health clinic. Methods: All subjects (n = 104) completed the Beck Depression Inventory (BDI) and the Suicide Probability Scale (SPS) prior to being seen by a physician and were categorized according to presenting problem (physical complaints only, psychological complai...