BACKGROUND Any strategy for curing HIV infection must include a method to eliminate viral-infected cells. Based on our earlier proof-of-principle results targeting HIV-1 infected cells with radiolabeled antibody (mAb) to gp41 viral antigen, we embarked on identifying a suitable candidate mAb for preclinical development. METHODOLOGY/PRINCIPAL FINDINGS Among the several human mAbs to gp41 teste...

Binary mixtures of the protic ionic liquid ethylammonium nitrate (EAN) and acetonitrile (AN) were studied at 25 1C over the entire composition range by means of broadband dielectric spectroscopy covering 0.2 r n/GHz r 89. The dielectric spectra could be decomposed into two relaxation processes, both of which proved to be composite modes. For dilute solutions the higher-frequency Debye relaxatio...

The influence of the semisynthetic epipodophyllotoxin derivative VP 16-213 on different cellular and biochemical parameters was determined with the use of suspension cultures of a murine mastocytoma. Cells were exponentially dividing and not synchronized. Treatment with VP 16-213 (l ¿ig/ml) reduced the mitotic index by more than 75% within 1.5 hr and completely prevented cell multiplication up...

Recently, the production of ultrahigh-density ( ∼ 10 19 cm − 3 ) spin-polarized deuterium (SPD) atoms was demonstrated, from photodissociation iodide, but upper density limit not determined. Here, we present studies hydrogen (SPH) densities up to 20 , by photodissociating 5 bar chloride with a focused 213 nm, 150 ps laser pulse. We extract depolarization cross-section and chlorine atom collisio...

We present an implementation of Kohonen Self-Organizing Feature Maps for the Spert-II vector microprocessor system. The implementation supports arbitrary neural map topologies and arbitrary neighborhood functions. For small networks, as used in real-world tasks, a single Spert-II board is measured to run Kohonen net classiication at up to 208 million connections per second (MCPS). On a speech c...

This paper presents an algorithm to average a set of quaternion observations. The average quaternion is determined by minimizing the weighted sum of the squared Frobenius norms of the corresponding attitude matrix differences, subject to the unit-norm constraint in the determined solution. Two cases are presented: one that incorporates scalar weights and one that incorporates general weights on...