نتایج جستجو برای: 215
تعداد نتایج: 8895 فیلتر نتایج به سال:
CRYSTAL STRUCTURE OF HUMAN LIVER ∆-3-KETOSTEROID 5β-REDUCTASE (AKR1D1) AND IMPLICATIONS FOR SUBSTRATE BINDING AND CATALYSIS* Luigi Di Costanzo, Jason E. Drury, Trevor M. Penning, and David W. Christianson From the Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, and Center of Excellence in Environmental Toxicology an...
Single-cell RNA seq analyses on human epidermis have given new insights into cell fates of the tissue by characterizing precise transcriptomic profile at single-cell scale, but information spatial localizations transcripts in each single cells is lacking. 3D are therefore great importance to characterize with resolution. To study epidermal biology and diseases, organotypic models can be grown u...
BACKGROUND: Organisms blamed in acute appendicitis are right predictable and very susceptible to a wide range of broad-spectrum antibiotics. AIM: The aim the study was assess clinical benefit routine intra-operative swab during an appendectomy guiding antibiotic selection. METHODS: Four hundred thirty patients underwent halved into two groups, each 215. In Group 1, routinely obtained for cultur...
BACKGROUND/AIMS Hirschsprung's disease (HSCR), known as aganglionosis, is an infrequent congenital gut motility disorder characterized by absence of enteric neurons. In this study, we focus on the role of the intronic miR-215 and its host gene isoleucyl-tRNA synthetase 2 (IARS2) in the pathogenesis of HSCR. METHODS Quantitative real time PCR and Western blot were used to detect the miRNA, mRN...
From the Division of Endocrinology, Department of Pediatrics, The Children’s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania, Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Phila...
The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here, we report that hypoxia-induced miR-215 is vital for reprograming GICs to fit the hypoxic microenvironment via suppressing the expression of an epigenetic regulator KDM1B and modulating activities of multiple pathways. I...
Rooted in a formal-legal tradition, international relationists have been thinking about anarchy and sovereignty wrong for over a century. Building on an alternative view of relational authority and recent research on the practice of sovereignty, a new conception of security hierarchy is developed that varies along a continuum from alliances at one end to protectorates at the other. This constru...
a Virginia Tech Dept. of Aerospace and Ocean Engineering, 215 Randolph Hall Blacksburg, VA 24061, United States, [email protected] (Corresponding Author) b Virginia Tech Dept. of Aerospace and Ocean Engineering, 215 Randolph Hall Blacksburg, VA 24061, United States, [email protected] c Virginia Tech Dept. of Computer Science, 2202 Kraft Drive Blacksburg, VA 24060, United States, [email protected] ...
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