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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes fatal neurological disease in humans, is one of the most important emerging pathogens of public health significance. JEV represents the JE serogroup, which also includes West Nile, Murray Valley encephalitis, and St. Louis encephalitis viruses. Within this serogroup, JEV is a vaccine-preventable pathogen, but the molecul...
The main antivirals employed to combat seasonal and pandemic influenza are oseltamivir and zanamivir which act by inhibiting the virus-encoded neuraminidase. These have to be deployed close to the time of infection and antiviral resistance to the more widely used oseltamivir has arisen relatively rapidly. Defective interfering (DI) influenza virus is a natural antiviral that works in a differen...
Short-lived nuclides, now extinct in the solar system, are expected to be present in interstellar matter (ISM). Grains of ISM origin were recently discovered in the inner solar system and at Earth orbit and may accrete onto Earth after ablation in the atmosphere. A favorable matrix for detection of such extrater-restrial material is presented by deep-sea sediments with very low sedimentation ra...
The negative regulation of transcription of the human von Willebrand factor (vWF) gene was investigated in human umbilical vein endothelial cells (HUVECs) and HeLa cells. A fragment spanning -89 to +244 nucleotides (nt), containing the first exon, is active in HUVECs only but not in HeLa cells. The activity of this promoter is sharply reduced by mutagenesis of the GATA binding site at +221. Ext...
[This corrects the article on p. 244 in vol. 10, PMID: 25045378.].
Peu de travaux recherche étudient les relations entre pratiques contrôle gestion et leur environnement sous l’angle d’un package. Cet article examine effets l’environnement sur à l’université. En mobilisant le cadre théorique l’École la Proximité, nous montrons pertinence lire travers diverses dimensions (géographique, organi...
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