The Scaling of microchip technologies, from micron to submicron and now to deep sub-micron (DSM) range, has enabled large scale systems-on-chip (SoC). In future deep submicron (DSM) designs, the interconnect effect will definitely dominate performance. Network-on-Chip (NoC) has become a promising solution to bus-based communication infrastructure limitations. NoC designs usually targets Applica...

NoC-specific parameters feature a huge impact on performance and implementation costs of NoC. Hence, performance and cost evaluation of these parameter-dependent NoC is crucial in different design-stages but the requirements on performance analysis differ from stage to stage. In an early design-stage an analysis technique featuring reduced complexity and limited accuracy can be applied, whereas...

5,7-dihydroxy-8-nitrochrysin (NOC), a novel synthetic chrysin analogue, induces apoptosis in human cancer cells. We previously demonstrated that NOC possesses stronger cytotoxicity towards human colon carcinoma and human gastric carcinoma cells than chrysin. Herein, we demonstrate the mechanism by which NOC preferentially suppresses the viability of the MDA-MB-453 human breast cancer cell line ...

Coordination of chromosome segregation and cytokinesis is crucial for efficient cell proliferation. In Bacillus subtilis, the nucleoid occlusion protein Noc protects the chromosomes by associating with the chromosome and preventing cell division in its vicinity. Using protein localization, ChAP-on-Chip and bioinformatics, we have identified a consensus Noc-binding DNA sequence (NBS), and have s...

This report aims at depicting the scenario of Network-On-Chip (NoC) architectures proposed from both academic institutes and industry. A review of suitable NoC simulators is presented, with the aim of having appropriate tool for an accurate evaluation of architectures and protocols performances on different application-domains. This is important when comparing NoC with traditional communication...

Network on Chip (NoC) is a communication paradigm for on-chip communication. It has replaced the traditional bus and crossbar interconnection as it has higher bandwidth, modularity, scalability and benefits of resource reuse. This paper presents the detail survey of the NoC architectures being proposed and implemented in last more than a decade. Apart from comparing the NoC architectures on dif...

Future generation embedded multicore will be based on hundreds of processors connected through Network on Chip (NOC) . Design productivity of embedded multicore is a major challenge for the semiconductor industry. In this paper, an automatic very large scale NoC design methodology based on FPGA IP is proposed to accelerate the embedded multicore design productivity using very large scale multi-...

The Network-on-Chip (NoC) approach is a promising solution to the increasing complexity of on-chip communication problems due to its high scalability. A NoC architecture design with ultra-low latency and high throughput is critical in order to support a wide range of applications. In this paper, we propose novel spatial-based NoC resource allocation algorithms to reduce the communication conges...

For flexible mapping of various task-level pipelines on a multi-core processor, the authors proposed the memory-centric network-on-chip (NoC). The memory-centric NoC manages producer–consumer data transactions between the tasks in the case of task-level pipelines are distributed over multiple processing cores. Since the memory-centric NoC manages the data transactions, it relieves burden of the...

Received December 30, 2001 A neuropeptide nociceptin or orphanin FQ (Noc/OFQ) was previously identified as an endogenous ligand for the orphan opioid receptor-like receptor. Studies on the analysis of the precursor of Noc/OFQ, we identified another novel neuropeptide and named it “nocistatin”. Noc/OFQ is involved in a broad range of pharmacological actions in various tissues from the central ne...