Ten new cembranolides, (-)-(1R*,4R*,10R*)-4-methoxycembra-2E,7E,11Z-trien-20,10-olide (1), (-)-(1S*,4R*,10R*)-1-hydroxy-4-methoxycembra-2E,7E,11Z-trien-20,10-olide (2), (-)-(1S*,4S*,10R*)-1,4-dihydroxycembra-2E,7E,11Z-trien-20,10-olide (3), (-)-(1S*,4S*,10R*)-1,4-dihydroxycembra-2E,7E,11Z-trien-20,10-olide (4), (+)-(10R*)-cembra-1E,3E,7E,11Z,16-pentaen-20,10-olide (5), (+)-(10R*)-cembra-1Z,3Z,7...

In our ongoing study to evaluate the antiprotozoal activity of alkamides from Asteraceae, a dichloromethane extract from the roots of Anacycluspyrethrum L. showed a moderate in vitro activity against the NF54 strain of Plasmodium falciparum and against Leishmaniadonovani (amastigotes, MHOM/ET/67/L82 strain). Seven pure alkamides and a mixture of two further alkamides were isolated by column chr...

The vehicle routing problem with the capacity constraints was considered in this paper. It is quite difficult to achieve an optimal solution with traditional optimization methods by reason of the high computational complexity for large-scale problems. Consequently, new heuristic or metaheuristic approaches have been developed to solve this problem. In this paper, we constructed a new heuristic ...

Sex attractants were established for one Brachodidae, three Choreutidae and two Tineidae moth species during field screening tests with (2E,13Z)-octadecadien-1-al, (2E,13Z)-, (3E,13Z)-, (3Z,13Z)-octadecadien-1-ols and their acetates (2E,13Z-18:Ald, 2E,13Z-, 3E,13Z-, 3Z,13Z-18:OH/OAc) as well as of binary mixtures of these compounds in West-Kazakhstan and Lithuania. Males of Brachodes appendicul...

The Heterogeneous Fleet Vehicle Routing Problem (HFVRP) is an important variant of the classical Capacitated (CVRP) that aims to find routes minimize total traveling cost a heterogeneous fleet vehicles. This problem great interest given its importance in many industrial and commercial applications. In this paper, we present Adaptive Iterated Local Search (AILS) heuristic for HFVRP. AILS local s...

The successful application of Branch and Cut methods to the TSP has drawn attention also to the polyhedral properties of the symmetric capacitated vehicle routing problem, which is the capacitated counterpart of the TSP. We investigate three classes of valid inequalities for the CVRP, multistars, pathbin inequalities and hypotours and give computational results we obtained with a Branch and Cut...

An N-alkylamide profiling from an ethanolic Anacyclus pyrethrum DC. root extract was performed using a gradient reversed phase high performance liquid chromatography/UV/electrospray-ionization ion-trap mass spectrometry (HPLC/UV/ESI-MS) method on an embedded polar column. MS1 and MS2 fragmentation data were used for identification purposes while UV was used for quantification. Thirteen N-alkyla...

Extensive ab initio calculations were performed for the X̃ 2E′ and à 2E′′ states of Ag3, using a newly constructed basis set for Ag. An important goal of these calculations is to guide the analysis of the experimentally observed à 2E′′-X̃ 2E′ electronic spectrum. Vibrational frequencies of Ag3 for both the X̃ and à state are reported. Spectroscopically obtainable parameters describing the Jahn-Tel...

the capacitated vehicle routing problem (cvrp) is a well-known combinatorial optimization problem that holds a central place in logistics management. the vehicle routing is an applied task in the industrial transportation for which an optimal solution will lead us to better services, save more time and ultimately increase in customer satisfaction. this problem is classified into np-hard problem...