OBJECTIVE To increase our understanding of the etiology of idiopathic thrombocytopenic purpura (ITP) some cytokine gene polymorphisms were analyzed for susceptibility to the disease. The aim of this study was to investigate the role of tumor necrosis factor-alpha (TNF-α) -308 G/A and transforming growth factor-beta 1 (TGF-β1) -915 G/C polymorphisms in the development and clinical progression of...

www.sciencemag.org (this information is current as of March 30, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/sci;309/5738/1187a A correction has been published for this article at: http://www.sciencemag.org/cgi/content/full/308/5721/523 version of this article at: including high-resolution figures, can be found in the...

Tumor necrosis factor (TNF) alpha-308 and interleukin (IL)-10(-1082) have potent inflammatory responses in the process of airway inflammation in asthma. The purpose of this study was to check for association of polymorphisms related to cytokine genes with susceptibility and severity of bronchial asthma in Egyptian children. Blood samples of 69 asthmatic children receiving treatment and follow-u...

Juvenile idiopathic arthritis (JIA) is the most frequent rheumatic disease in children and could lead to severe disability. The aim of this study was to determine the role of gene polymorphisms in predicting the clinical response of anti-TNF therapy in JIA patients. 68 patients with JIA and 20 healthy controls (HC) were included in the study, and patients with JIA received anti-TNF treatment fo...

The development of structural changes in ZnO targets, upon laser irradiation at the wavelengths of 266 and 308 nm, is studied by Raman spectroscopy. At the wavelength of 308 nm, oxygen vacancies are found to develop monotonically with increasing laser intensity. At 266 nm, a structural change in the irradiated ZnO targets, possibly related to nanostructuring, is observed above the laser fluence...

Transient ischemic attack (TIA) is a brief cerebral ischemic incident. This study assesses the role of TNF-α and IL-6 single nucleotide polymorphisms (SNPs) as predictors of recurrent TIAs that have high risk of developing stroke. The current study enrolled 54 high risk (according to frequency of TIA) TIA (group1), 52 low risk TIA patients (group2) and 34 controls (group3). Polymerase chain rea...

AIM To investigate genetic factors that might help define which Crohn's disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODS This was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on tr...

Near the vicinity of 308 latitude, the coincidence of the period of sea breeze and the inertial period of the ocean leads to a maximum near-inertial ocean response to sea breeze. This produces a propagating inertial internal (Poincare) wave response that transfers energy laterally away from the coast and provides significant vertical mixing. In this paper, the latitudinal dependence of this wav...

Abstract Background Acute myocarditis (AM) is an inflammatory disease of the myocardium that associated with heterogenous clinical presentations, which may be non-specific. Furthermore, several cardiac diseases can mimic its phenotype. Research in AM frequently utilises ICD-10 codes from hospital admissions for case identification. We retrospectively confirmed or refuted a diagnosis according t...

Celiac disease (CD) remains one of the most significant autoimmune diseases worldwide. The pathogenesis of CD is not clearly understood and is probably attributed to genomic variations and host genetic make-up. Case-control and cohort studies of the association between the TNF-α -308 G > A (rs1800629) polymorphism and CD susceptibility have yielded inconsistent results. In this study, PubMed, E...