incorporation of functional foods and nutraceuticals such as carotenoids which suffer from poor water solubility and low bioavailability into nano-sized delivery systems can improve their solubility, stability and oral bioavailability. the aim of this study was to prepare β-carotene nanodispersion and investigate the effects of preparation parameters by means of response surface methodology usi...

An A-optimal minimax design criterion is proposed to construct fractional factorial designs, which extends the study of the D-optimal minimax design criterion in Lin and Zhou (Canadian Journal of Statistics 41, 325–340, 2013). The resulting Aoptimal and D-optimal minimax designs minimize, respectively, the maximum trace and determinant of the mean squared error matrix of the least squares estim...

BACKGROUND Standards for the reporting of factorial randomised trials remain to be established. We aimed to review the quality of reporting of methodological aspects of published factorial trials of complex interventions in community settings. METHODS We searched MEDLINE, EMBASE, PsychInfo and the Cochrane Controlled Trials Register to identify factorial randomised trials of complex intervent...