The carboxy-terminal domain of the p53 protein comprising amino acid residues 311 to 393 is able to promote the reassociation of single-stranded RNA or DNA into duplex hybrids. This domain is as efficient as the intact p53 protein in both the rate and the extent of the double-stranded product produced in this reaction. Both wild-type and mutant p53 proteins from cancerous cells carry out this r...

BACKGROUND MiR-378 has been reported to be related to cell survival, tumor growth and angiogenesis and may participate in hepatocellular carcinoma (HCC) development and prognosis. Genetic variants in primary miR-378 (pri-miR-378) may impact miR-378 expression and contribute to HCC risk and survival. This study aimed to assess the associations between a genetic variant in primary miR-378 and HCC...

background chronic hepatitis b (chb) is accompanied by inflammation of liver because of infection with hepatitis b virus (hbv). previous studies revealed an inverse association between vitamin d and hbv dna levels. objectives the current study aimed to investigate the levels of 25 (oh) d3 (the steady form of vitamin d), mir-378 and hbv dna in the patients with chb. patients and methods one hund...

an experiment was conducted at assossa agricultural research center (aarc) station during 2008 cropping season in order to study the effects of co-inoculation of bradyrhizobium japonicum (tal-378 and tal-379) and phosphate-solubilizing bacteria (psb) (pseudomonas spp.), and conventional farmers’ fertilizer level (combined and individual application of 46n kg ha-1 and 46 p2o5 kg ha-1) on nodulat...

Human CYP2E1 is one of the pharmacologically and toxicologically important cytochrome P450 isoforms. Earlier studies have reported that the CYP2E1 expression is extensively regulated by post-transcriptional and post-translational mechanisms, but the molecular basis remains unclear. In the present study, we examined the possibility that microRNA may be involved in the post-transcriptional regula...

The original version of the paper in Section 3.8 reports that "The peptide mass tolerance and fragment mass tolerance values were 10 ppm and 30 mDa, respectively" [1] (p. 387). To help others who may want to use the same methods in the future, the authors would like to correct the wording to: "The peptide mass tolerance and fragment mass tolerance values were 30 ppm and 0.15 Da, respectively. I...

The recursive inverse eigenvalue problem for matrices is studied, where for each leading principle submatrix an eigenvalue and associated left and right eigenvectors are assigned. Existence and uniqueness results as well as explicit formulas are proven, and applications to nonnegative matrices, Zmatrices, M -matrices, symmetric matrices, Stieltjes matrices and inverse M -matrices are considered...

OBJECTIVE Frequency of ischemic stroke subtypes is influenced by ethnic and geographic variables. Our objective was to identify various stroke subtypes and its determinants at a tertiary care hospital. METHODS We prospectively collected data on ischemic stroke subtypes admitted to The Aga Khan University Hospital in Karachi. RESULTS A total of 596 patients were enrolled in 22 months in the ...