The effects of many chemotherapeutic drugs on ribosome biogenesis have been underestimated for a long time. Indeed, many drugs currently used for cancer treatment--and which are known to either damage DNA or hinder DNA synthesis--have been shown to exert their toxic action mainly by inhibiting rRNA synthesis or maturation. Moreover, there are new drugs that have been proposed recently for cance...

In the last decade, our understanding of psoriasis has increased by leaps and bounds, resulting in many new targeted therapies being introduced for those with recalcitrant psoriasis. However, despite the plethora of new treatment options and biologics to treat the most difficult cases of psoriasis, dermatologists are still confronted with the heterogeneity of treatment effects for psoriasis in ...

From a policy standpoint, a growing elderly population has become a challenge to our society. However, we maintain we can be moderately optimistic, because cognitive impairment, or worse, dementia, are not always caused by Alzheimer’s disease or are the consequence of major ischemic or haemorrhagic stroke. They are often due to micro-infarcts and/or micro-haemorrhages ("mini-strokes") at the le...

A group of experts gathered in Indianapolis in December 2011 to address lingering concerns related to uterus transplantation (UTn). They represent a multi-national group of four research teams who have worked for over 15 years on bringing UTn to reality for patients. Presented here are a set of parameters that must be considered in order for UTn to become an acceptable procedure in the human se...

In Mobile Ad hoc Networks (MANET), reliability in real time data transmission can be assured by confirming the connectivity of the network. Since, MANETs are characterized by dynamic topology changes; the established connection must be monitored for its consistency. In order to provide and maintain connectivity, in this paper, we propose a reliable real time data transmission technique in MANET...