BACKGROUND While doxorubicin (DOX) is widely used in cancer chemotherapy, long-term severe cardiotoxicity limits its use. This is the first report of the chemoprotective efficacy of a relatively new thiol antioxidant, N-acetylcysteine amide (NACA), on DOX-induced cell death in cardiomyocytes. We hypothesized that NACA would protect H9c2 cardiomyocytes from DOX-induced toxicity by reducing oxida...

This paper presents the development of a bioinspired flight control system and a characterization of its performance when operating in turbulent and gusting airflow conditions. This design consists of a skeletal structure with a network of feather-like panels installed on the upper and lower surfaces, extending beyond the trailing edge. Each feather is able to deform into and out of the boundar...

This research modifies the leading-edge structure of NACA 0015 and 4415 to resemble nose a beluga whale. The focus this modification is improve airfoil's aerodynamic performance investigate changing fluid flow patterns. Numerical equation used RANS combined with k-ε turbulence model. Mesh independence test shows that mesh 200 elements best mesh. Validation results reveal CFD data can follow tre...

The main objective of the “INNWIND.EU” project is to investigate and demonstrate innovative designs for 10-20MW offshore wind turbines and their key components, such as lightweight rotors. In this context, the present paper describes the development of two new airfoils for the blade root region. From the structural point of view, the root is the region in charge of transmitting all the loads of...

The present study addresses the experimental and numerical verification of the performance of a new airfoil design for lift driven vertical-axis wind-turbines (VAWT). The airfoil is obtained by a genetic algorithm optimization of the objective function proposed by Simão Ferreira and Geurts [19], which optimizes the aerodynamic performance of airfoils having a relatively larger thickness, provid...

We have previously identified the transcript encoding NACA (the alpha chain of the nascent-polypeptide-associated complex) as a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. This protein was already known to be a transcriptional co-activator that acts by potentiating AP-1 activity in osteoblasts, and is known to be involved in the targeting of nascent polyp...

Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized human brain microvascular endothelial (HBMVEC) cells to test whether N-acetylcys...

An approach that uses gridless or meshless methods to address the problem of boundary implementation associated with the use of Cartesian grid is discussed. This method applies the gridless concept only at the interface, whereas a standard structured grid method is used everywhere else. The Cartesian grid is used to specify and distribute the computational points on the boundary surface but not...

The noise generated by the interaction of a turbulent inflow with the leading edge of a flat plate or an airfoil is a dominant sound source, for example in rotor-stator configurations of fans and air condition units. Aeroacoustic research of this noise source often includes performing wind tunnel experiments, where the required incident turbulence is generated by passive grids or meshes. In cer...