We evaluated changes in the binding properties of sedative and non-sedative histamine H1-receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells. Internalization of H1 receptors was induced without their degradation by treatment with 0.1 mM histamine for 30 min at 37 degrees C, and then the intact cell binding assay was performed at 4 degrees C....

The star-critical Ramsey number r∗(H1,H2) is the smallest integer k such that every red/blue coloring of the edges of Kn −K1,n−k−1 contains either a red copy of H1 or a blue copy of H2, where n is the graph Ramsey number R(H1,H2). We study the cases of r∗(C4, Cn) and R(C4,Wn). In particular, we prove that r∗(C4, Cn) = 5 for all n > 4, obtain a general characterization of Ramsey-critical (C4,Wn)...

We have prepared two acridine spin labels, 6-chloro-9-[4-(2,2,6,6-tetramethyl-1-piperidinyloxy)amino]-2-methoxyacridine (I) and 9-[4-(2,2,6,6-tetramethyl-1-piperidinyloxy)amino]-acridine (II) and have used them to study the binding of lysine-rich histone (H1) to DNA using electron spin resonance (ESR). ESR spectra of I in the presence of DNA, polydA-polydT and polydG-polydC were characteristic ...

Two cDNA clones isolated from a HepG2 lambda gt11 library encode the classical asialoglycoprotein receptor, H1, as well as a homologous membrane glycoprotein, H2 (Spiess, M., and Lodish, H.F. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6465-6469). To study the relationship of H2 to H1 and its possible role in receptor-mediated endocytosis of desialyated glycoproteins, we generated anti-peptide ant...

nm23-H1 was originally identified as a protein that is expressed at a lower than usual level in metastatic cancer cells. The nm23 genes play critical roles in cellular proliferation, differentiation, oncogenesis, and tumor metastasis. Peripheral T-cell lymphoma (PTCL) is relatively rare, accounting for only 10% to 15% of non-Hodgkin's lymphomas. We examined whether nm23-H1 is a prognostic facto...

A pathogenic hallmark of rheumatoid arthritis (RA) is persistent activation of self-reactive CD4(+) T cells. The cause of this aberrant activity remains elusive. We report here detection of autoantibodies against B7-H1, a recently described member of the B7 family, in 29% of patients with RA versus 4% of healthy donors. High-level expression of cell surface B7-H1 are found on activated human CD...

The main theorem of this paper states that ifM is a closed orientable hyperbolic 3-manifold of volume at most 3.08, then the dimension of H1(M ;Z2) is at most 7, and that it is at most 6 unless M is “strange.” To say that a closed, orientable 3-manifold M , for which H1(M ;Z2) has dimension 7, is strange means that the Z2-vector space H1(M ;Z2) has a 2-dimensional subspace X such that for every...